摘要
目的探讨α-甲酰基辅酶A消旋酶（AMACR）和雄激素受体（AR）在前列腺癌中表达的临床病理学意义，并对中日两组前列腺癌患者进行对比分析。方法采用组织病理学方法对113例前列腺癌进行复查并对其中101例腺泡癌进行分级，免疫组织化学方法观察103例前列腺腺泡癌AMACR和AR的表达情况。肿瘤细胞胞质中出现棕黄色细颗粒为AMACR阳性，细胞核中出现棕黄色颗粒为AR染色阳性。结果中国人组83例中腺泡癌73例，尿路上皮癌4例，神经内分泌癌6例。除2例因组织太少不宜分级外，71例腺泡癌中Gleason评分小于7分3例；7分10例；大于7分58例。日本人组30例前列腺癌均为前列腺腺泡癌。Gleason评分小于7分16例，7分12例，8分2例。中国人组73例中AMACR阳性表达率为63．01％（46／73），日本人组为96．67％（29／30），中习两组的表达水平差异有统计学意义（x^2=12．160，P〈0．01）。中国人前列腺癌三组评分与AMACR阳性表达率差异无统计学意义（x^2=2．035，P〉0．05）。中日两组前列腺癌组织中AR的阳性表达率分别为39．73％（29／73）和80．00％（24／30），两组阳性表达率差异有统计学意义（矿=13．807，P〈0．01）。中国人前列腺癌三组评分与AR阳性表达率差异无统计学意义（x^2=2．079，P〉0．05）。结论AMACR、AR的表达可对前列腺癌的诊断与鉴别诊断提供参考，也是患者预后判定的依据之一；中、日两国前列腺癌的生物学行为存在着差异，中国人组分化差、恶性程度高、预后不良。
Objective To observe the expression and clinicopathological significance of AMACR and AR in prostate cancer, and analyze the difference in the prostate cancer between the Chinese and the Japanese. Methods 113 cases of prostate cancer were diagnosed and 103 specimens of prostatic adenocarcinomas were graded based on Gleason method. Immnohistological staining was performed to observe the expression of AMACR and AR, and the relation between the expression and the Gleason sum of the prostate cancer was analyzed. Positive signals were shown in cytoplasma and cell nucleus. Results Of 83 prostate cancer specimens,there were 73 prostatic adenocarcinomas,4 prostatic papillary carcinomas,and 6 neuroendocrine carcinomas of prostate. There were 3 cases with Gleason sum below 7, 10 cases equal to 7, and 58 cases over 7. In 30 prostate cancer specimens from Kobe University of Japan,there were 16 cases with Gleason sum below 7,12 equal to 7, and 2 over 7. The positive rate of AMACR was 63.01% in Chinese group, and 96.67% in Japanese group respectively （x^2 = 12. 160,P 〈0.01 ）. Gleason score was not correlated with AMACR level in Chinese group and Japanese group,but Gleason score of the expression of AMACR in Chinese group was less than in Japanese group. The positive rate of AR was 39.73% in Chinese group,and 80.00% in Japanese group respectively （x^2 = 13. 807,P 〈0.01 ）. Gleason score was not correlated with AR level in Chinese group and Japanese group,but Gleason score of the expression of AR in Chinese group was less than in Japanese group. The positive expression of AR in prostate cancer of Chinese group was lower than that in Japanese group. Conclusion The markers of AMACR and AR play an important role in diagnosis and differential diagnosis of prostate cancer. The content of AR in prostate can be regarded as an objective index to judge prognosis of prostate cancer patients. There was difference in the prostate cancer between Chinese and Japanese. The prostate cancer in Chinese patients had a worse differentiat
出处
《中华实验外科杂志》
CAS
CSCD
北大核心
2009年第10期1287-1289,I0003,共4页
Chinese Journal of Experimental Surgery
基金
教育部留学基金资助项目（留金法1998-003）
关键词
前列腺癌
雄激素受体
免疫组织化学
预后
Prostate carcinoma
Androgen receptor
Immunohistochemistry
Prognosis
