摘要
基质金属蛋白酶(MMP)是调控生长发育过程中一种重要的蛋白酶,具有生理功能,当神经系统出现损伤时起修复神经系统的作用。但某些情况下,体内的一些MMP同时急剧升高反而会导致机体病理损伤。因此,MMP有双重功能,一方面能介导神经修复和功能恢复,另一方面又造成机体损伤。文中介绍了MMP-2及MMP-9在正常神经系统中的生理功能,探讨了两者在脊髓损伤、中枢神经系统肿瘤中的作用及MMP抑制剂在临床应用中的可能性。
The matrix metalloproteinases （MMP） are important enzymes that regulate developmental processes, maintain normal physiology in adulthood and have reparative roles in specific stages after an insult to the nervous system. Conversely, the concordant presence and significant up-regulation of several MMP members in virtually all neurological conditions result in pathological lesions. Thus, the MMPs have double functions, capable of mediating repair and recovery on the one hand and being involved in producing injury on the other. This article highlights the beneficial roles of MMP-2 and MMP-9 in normal and reparative processes within the nervous system and discusses the detriments of both encountered in spinal cord injury and central nervous system cancers, and we also review the availability of MMP inhibitors for clinical use.
出处
《医学研究生学报》
CAS
2009年第9期992-995,共4页
Journal of Medical Postgraduates
基金
南京军区重点课题资助项目(批准号:07Z029)
关键词
蛋白酶
神经发育
脊髓损伤
中枢神经系统肿瘤
Protease
Neural development
Spinal cord injury
Central nervous system cancer
