摘要
目的:探讨低密度脂蛋白免疫复合物(LDL-IC)在急性冠状动脉综合征(ACS)发生发展过程中的作用及其临床意义。方法:采用酶联免疫吸附法测定139例冠心病患者(ACS组76例,非ACS组63例)及111例正常对照组的血清LDL-IC浓度。根据冠状动脉造影结果将冠心病组分为多支病变组(病变≥2支)及单支病变组(1支病变)进行比较。结果:①ACS患者LDL-IC水平显著高于非ACS冠心病患者[(2.78±1.08)AU(相对单位)vs(1.74±0.45)AU,P<0.01]和正常对照组[(2.78±1.08)AUvs(1.55±0.71)AU,P<0.01]。②多支病变组LDL-IC水平高于单支病变组[(2.60±1.10)AUvs(1.82±0.50)AU,P<0.01]及正常对照组[(2.60±1.10)AUvs(1.55±0.71)AU,P<0.01]。③LDL-IC水平与氧化低密度脂蛋白(ox-LDL)水平呈显著正相关(r=0.348,P<0.01)。结论:LDL-IC与ACS的发生发展及冠状动脉病变程度之间可能存在一定的相关性。
Objective：To study the significance of LDL immune complexes in the pathogenesis of acute coronary syndrome（ACS）. Methods： Enzyme linked immunosorbent Assay was used to measure the plasma LDL-IC in 139 patients with coronary heart disease （76ACS ;63NACS） and in 111 control subjects. The patients with coronary heart disease were divided into multi-vessel diseased group（ 2-vessel diseased group and 2 vessels more） and mono-vessel diseased group （ 1-vessel diseased group） by coronary angiography. Results： （1）LDL-IC level was higher in patients with ACS than that in patients with non-ACS [ （2.78 ± 1.08 ） AU vs （ 1.74 ± 0.45 ） AU, P 〈 0.01 ] and than that in control subjects [ （ 2.78 ± 1.08）AU vs （1.55 ± 0.71 ）AU,P 〈 0.01 ]. （2）LDL-IC level was higher in patients with multi-vessel diseased group than that in mono-vessel diseased group[ （2.60 ± 1.10）AU vs （ 1.82 ±0.50） AU,P 〈 0.01 ] and than that in control subjetcs [ （2.60 ± 1.10） AU vs （ 1.55 ± 0.71 ） AU, P 〈 0.01 ]. （3）LDL-IC level was correlated with ox-LDL（ r = 0.348, P 〈 0.01 ）. Conclusion ：LDL-IC might have some relation to the pathogenesis of ACS and the severity of coronary lesions.
出处
《医学研究生学报》
CAS
2007年第7期723-726,共4页
Journal of Medical Postgraduates
基金
国家自然科学基金资助项目(批准号:30471649)
江苏省自然科学基金青年科技创新人才项目资助(批准号:BK2006529)
