摘要
猪主要组织相容性复合体又称SLA,即为猪白细胞抗原,其编码基因位于猪的第7号染色体上,是一组紧密连锁、高度多态的基因群,包括多个不同位点,是编码移植抗原,控制免疫细胞各亚群间协同作用的一个基因复合体。它不仅与移植排斥有关,而且广泛参与免疫应答的诱导和调节,在遗传、进化、行为、保护及生态等方面都具有重要的科学意义。就SLA-Ⅱ类区域基因目前的研究现状,对它的位置、分类、功能、多态、表达及应用等方面进行了系统阐述。
The major histocompatibility complex （MHC） of swine is called swine lymphocyte antigen（SLA）, which situate in the seventh chromosome of swine. It is a set of closely linked and polymor- phic gene cluster and include many different site, and encode transplantation antigen and control synergistic effect among immunologic cell subgroups. MHC associates not only with the transplantation rejection reactions but also with immunological responses in a variety of pathological processes, and having important significance in the fields of inherit, evolution, behavior, conservation and ecosystem. In this paper, according to the research status of SLA-Ⅱ genes, the position, categorization, function,polymorphism, expresion and application of SLA-Ⅱ genes were reviewed.
出处
《云南农业大学学报（自然科学版）》
CAS
CSCD
北大核心
2009年第5期759-763,共5页
Journal of Yunnan Agricultural University:Natural Science
基金
云南农业大学青年科学研究基金项目(2006Q16)
关键词
猪
MHC
SLA
移植排斥
免疫应答
SLA-Ⅱ类基因
swine
major histocompatibility complex
swine lymphocyte antigen
tranplantation rejection reactions
immunological responses
SLA-Ⅱ genes
