摘要
目的:研究血管内皮生长因子(VEGF)及增殖细胞核抗原(PCNA)在子宫肌瘤和正常子宫肌层中的表达。方法:应用免疫组织化学(SP)法检测40例子宫肌瘤组织和相应子宫肌层组织中血管内皮生长因子及增殖细胞核抗原的表达。结果:子宫肌瘤血管内皮生长因子阳性率为77.5%,增殖细胞核抗原阳性率为92.5%,相应子宫肌层组织阳性率分别为12.5%和47.5%,两组比较,有显著性差异(P<0.01)。结论:子宫肌瘤的发生及发展可能与血管内皮生长因子及增殖细胞核抗原有关。
Objective： To study the role of vascular endothelial growth factor （VEGF） and proliferating cell nuclear antigen （PCNA） in human uterine leiomyoma. Methods： Immunohistochemical SP method was used to detect the expressions of VEGF and PCNA in 40 cases of uterine lciomyoma and their corresponding myometrium. Results： The positive rates of the expressions of VEGF and PCNA in uterine leiomyoma were 77.5% and 92.5% respectively, and those of their corresponding myometrium were 12.5% and 47.5% respectively, they showed a statistical difference （P〈0.01）. Conclusion： The genesis and development of uterine leiomyoma nlay he correlated with VEGF and PCNA.
出处
《中国医药导报》
CAS
2009年第28期20-21,共2页
China Medical Herald
基金
深圳市宝安区科技局项目课题(2007066)
关键词
子宫肌瘤
血管内皮生长因子
增殖细胞核抗原
Uterine leiomyoma
Vascular endothelial growth factor
Proliferating cell nuclear antigen
