摘要
目的：探讨山莨菪碱对家兔带蒂皮瓣血循环重建的作用。方法：选取新西兰家兔２４只，于局麻下，在背部正中线两侧做蒂在头侧的７ｃｍ×５ｃｍ皮瓣。动物分为两组，实验组注射山莨菪碱，对照组以相同剂量和方法注射生理盐水，分别于皮瓣形成术后２、３、４、５、６天和术后８天对皮瓣进行墨汁灌注，并于皮瓣透明后经计算机图像处理测量血管密度。结果：实验组皮瓣血管密度高于对照组（Ｐ＜０．０５）。结论：山莨菪碱可以促进皮瓣与受区之间的血循环重建，从而增加皮瓣成活能力。
Objective:To explore the effects of anisodamine on neovascularization of pedicle flap in rabbits.Methods:Twenty four healthy New Zealand rabbits were used in the experiment.Each animal underwent creation of identical cranially based pedicle skin flap measuring 5cm×7cm following local anesthesia on each side of the dorsum midline.The rabbits were divided into two groups:the experimental group and the control group.Animals in the experimental group were injected with 0.1 % anisodamine solution and those in the control group were injected with 0.9 % NaCl solution with the same dose as the experimental group.At 2,3,4,5,6 day and 8 day after surgery,the flaps were perfused with Indian ink and the vascular density was studied with computer image analysis under transillumination.Results:The vascular density in the experimental group is higher than that in the control group.Conclusion:By promoting neovascularization between the recipient site and the flap,anisodamine can raise the survival quality of flaps.
出处
《河北医科大学学报》
CAS
1998年第4期201-203,共3页
Journal of Hebei Medical University
关键词
山莨菪碱
外科皮瓣
新生血管
血循环重建
anisodamine/drug eff
surgical flaps
neovascularization
rabbits
