摘要
1例83岁男性患者因患慢性阻塞性肺病、肺源性心脏病合并感染,给予环丙沙星400 mg,1次/d静滴;甲泼尼龙40 mg,2次/d静滴。第2天患者出现烦躁不安,情绪亢奋。停用环丙沙星,甲泼尼龙剂量减为40 mg,1次/d后患者精神状态稍有好转。第6天,患者再次出现精神行为异常,有被害妄想和自残行为。排除肺性脑病和茶碱中毒,考虑甲泼尼龙可能与精神障碍相关,停用甲泼尼龙,改口服泼尼松,患者精神症状逐渐好转。
A 83-year-old man with chronic obstructive pulmonary disease and pulmonary heart disease complicated with infection received an IV infusion of eiprofloxacin 400 mg once daily and an IV infusion of methylprednisolone 40 mg twice daily. The next day, the patient developed agitation and hyperemotion. Ciprofloxacin was discontinued and the dosage of methylprednisolone was decreased to 40 mg once daily, and the patient＇s mental status slightly improved. On day 6, the abnormal mental status and abnormal behavior reappeared in the patient; he had delusion of persecution and behavior of self-mutilation. Pulmonary encephalopathy and theophylline poisoning were excluded. Abnormal mental symptoms were considered to be possibly methylprednisolone-associated, Methylprednisolone was discontinued and switched to oral prednisone. His mental status gradually improved.
出处
《药物不良反应杂志》
2009年第4期278-279,共2页
Adverse Drug Reactions Journal
关键词
甲泼尼龙
不良反应
异常精神症状
methylprednisolone
adverse reactions
abnormal mental symptoms
