摘要
目的:探讨盐酸利托君(安宝)和硫酸镁在前置胎盘治疗中的临床疗效。方法:对43例使用盐酸利托君和41例使用硫酸镁的前置胎盘患者进行回顾性临床分析,对患者用药后的保胎效果、产后出血、围产儿结局、药物反应进行比较。结果:盐酸利托君组和硫酸镁组的保胎效果分别为95.3%和80.5%,延长孕龄17.8±15.4天和11.6±11.1天,两组比较差异有统计学意义(P<0.05)。产后出血量分别为545.1±416.1mL和490.7±355.1mL,差异无统计学意义(P>0.05)。新生儿体重分别为2427.9±496.3g和2740±527.9g,新生儿窒息率分别为6.98%和6.25%,两组比较均无统计学意义(P>0.05)。盐酸利托君和硫酸镁有不同的药品不良反应。结论:盐酸利托君对前置胎盘治疗效果优于硫酸镁,两种药物均有不良反应,使用中加强观察十分重要。
OBJECTIVE：To evaluate the clinical efficacy of Ritodrine Hydrochloride vs.Magnesium Sulfate for placenta previa.METHODS：43 patients with placenta previa treated with 100 mg Ritodrine Hydrochloride vs.41 placenta previa cases treated with Magnesium Sulfate were subjective to a clinical analysis retrospectively.The tocolytic effect,postpartum hemorrhage,perinatal outcome and the adverse drug effects were evaluated after medication.RESULTS：The tocolytic effect was 95.3% in Ritodrine Hydrochloride-treated group vs.80.5% in Magnesium Sulfate-treated group（P〈0.05）,and the gestational period was prolonged by 17.8±15.4 days vs.11.6±11.1 days（P〈0.05）.There were no significant differences between the two groups in postpartum blood loss volume（545.1±416.1 mL vs.490.7±355.1 mL,P〉0.05）,body weight of newborn infants（2 427.9 ±496.3 g vs.2 740 ±527.9 g,P〉0.05）and neonatal asphyxia rate（6.98% vs.6.25%,P〉0.05）.There were differences between the two drugs in adverse drug reactions.CONCLUSION：Ritodrine Hydrochloride is more effective than Magnesium Sulfate for placenta previa.Both have side effects,and it is quite important to tighten monitoring on the clinical use of these drugs.
出处
《中国医院用药评价与分析》
2009年第8期632-633,共2页
Evaluation and Analysis of Drug-use in Hospitals of China
关键词
盐酸利托君
硫酸镁
前置胎盘
围产儿结局
Ritodrine Hydrochloride
Magnesium Sulfate
Placenta previa
Perinatal outcome
