摘要
为探讨 β2 -肾上腺素能受体兴奋剂盐酸苄羟麻黄碱 (安宝 )治疗早产的临床效果 ,作者将 71例先兆早产孕妇随机分为两组 ,对照组 36例 ,用硫酸镁按常规剂量治疗 ;治疗组 35例 ,用盐酸苄羟麻黄碱治疗 ,即在 5 %葡萄糖液 5 0 0 ml中加入盐酸苄羟麻黄碱 5 0 mg静滴 ,并根据孕妇宫缩和心率调节滴速 ,待宫缩被抑制或心率 >130次 /分钟时减量 ,而后改用盐酸苄羟麻黄碱片剂 10 mg口服 ,每 4～ 6小时 1次 ,并逐渐减量。若病情反复可重复用药。结果显示 :用药后 2 4小时内 ,治疗组和对照组的早产发生率分别为 8.5 7% (3/ 35 )和 30 .5 6 % (11/ 36 ) ,显效时间分别为 2 .47± 0 .78小时和 6 .0 2± 0 .87小时 ,延长孕期分别为 2 5 .13± 10 .6 2天和 15 .92± 9.11天 ,新生儿出生体重分别为 2 85 1.88± 36 0 .0 3g和 2 6 10 .0 0± 32 2 .75 g。两组比较 ,上述各项指标均有显著性差异 (P<0 .0 5 ) ;同时 ,治疗期间未发现严重毒副反应。由此表明 ,盐酸苄羟麻黄碱治疗早产安全 ,其阻断宫缩作用较硫酸镁强 ,显效快 ,延长孕期长 ,值得临床推广应用。
This study was aimed to assess the effectiveness of treatment for preterm labor by using the β 2 adrenergic agonist ritodrine hydrochloride in comparison with magnesium sulfate. Seventy one women with preterm labor were randomly divided into two groups: study group(ritodrine hydrochloride group, n =35)and control group (magnesium sulfate, n =36).In the study group 50mg ritodrine was given into 500ml with 5% G.S. intravenously. The drip speed was started at 10 drips per minute(50μg/min) routinely, then adjusted according to the uterine contraction and heart rate of the women. When the uterine contraction was controlled and the heart rate exceeded 130 per minute,ritodrine was reduced gradually and oral ritodrine was used.The intravenous infusion would be repeated if the contraction reappeared. The results showed that within a period of 24 hours after the adminstration of the drugs, the incidence rates of preterm delivery were 8.57% and 30.56% for the study group and control group respectively. The time for initiation of inhibiting uterine contraction (2.47±0.78 hours) and the prolongation of gestation(25.13±10.62 days) of the study group were significantly different from those of the control group ( P< 0.001), and the birth weight of newborn ( 2851.88±360.03g) of the study group was greater than that of the control group ( P< 0.05).There was no serious complications in the study group. These results suggest that ritodrine hydrochloride is relatively safe and more effective than magnesium sulfate for the treatment of preterm labor.
出处
《华西医科大学学报》
CSCD
2000年第4期515-517,共3页
Journal of West China University of Medical Sciences
关键词
盐酸苄羟麻黄碱
硫酸镁
早产
药物治疗
Ritodrine hydrochloride Magnesium sulfate Labor Premature
