摘要
目的研究顺苯磺酸阿曲库铵肌松效应的年龄差异。方法196例患者按年龄分为四组:Ⅰ组53例,32～59岁;Ⅱ组54例,60～69岁;Ⅲ组52例,70～89岁;Ⅳ组37例,90～97岁。四组患者均于全麻诱导时静注顺苯磺酸阿曲库铵0.15mg/kg,并进行TOF肌松监测。术中持续泵注顺苯磺酸阿曲库铵,维持T110%～20%至术中结束。记录顺苯磺酸阿曲库铵药效动力学参数。结果Ⅳ组肌松起效时间短于其他三组(P<0.01);Ⅰ、Ⅱ组首次给药后T125%恢复时间显著快于Ⅲ、Ⅳ组(P<0.01);顺苯磺酸阿曲库铵用量随年龄增加而减少(P<0.01)。结论随年龄的增长,顺苯磺酸阿曲库铵起效时间缩短,肌松持续时间延长,维持用量减少。
Objective To investigate the pharmacodynamical difference in age for cisatracurium. Methods One hundred and ninty-six patients were divided into 4 groups of I （53 cases, aged 32 to 59 years old）, II（54 cases, aged 60 to 69 years old）, III （52 cases, aged 70 to 89 years old） and IV（37 cases, aged 90 to 97 years old）. All patients were intravenously injected 0.15 mg/kg cisatracurium during anesthesia induction,which was infused thenafter to keep T1 10%-20% till the end of operation. The neuromuscular block was monitored with TOF stimuli. Results The onset time was shorter in group IV than that in the other three groups（P〈0. 01）. The time of T1 25% recovery after first dose of cisatracurium was less in groups of I and II than that in groups of III and IV （P^0.01）. The amount of cisatracurium used in the first 60 min of operation decreased as the age became older（P〈0.01）. Conclusion As the age increases the onset time is faster, the neuromuscular block is longer and the requirement of cisatracurium is less.
出处
《临床麻醉学杂志》
CAS
CSCD
北大核心
2009年第8期655-657,共3页
Journal of Clinical Anesthesiology
