摘要
目的比较不同抗青光眼滴眼剂在睫状体平坦部玻璃体切割术后对高眼压的控制效果。方法将年龄在18～65岁、术前基线眼压为(16.62±3.40)mmHg、术后基线眼压为(30.76±7.47)mmHg的175例玻璃体切割术(parsplanavit-rectomy,PPV)后发生高眼压的患者分为4组,分别使用3种抗青光眼药物滴眼。第1组56例(56眼),单一应用β阻滞剂;第2组36例(36眼),单一应用α激动剂;第3组48例(48眼),协同应用β阻滞剂与碳酸酐酶抑制剂;第4组35例(35眼),协同应用α激动剂与碳酸酐酶抑制剂。分别观察用药3d后和9d后的降眼压效果。结果用药3d后,4组观察对象的眼压下降幅度为:第1组(9.87±5.16)mmHg,第2组(7.87±6.00)mmHg,第3组(13.03±8.43)mmHg,第4组(9.48±6.42)mmHg;在用药9d后为:第1组(13.16±5.09)mmHg,第2组(10.61±6.16)mmHg,第3组(16.60±8.93)mmHg,第4组(13.63±7.96)mmHg。对用药后3d和用药后9d的眼压测量数据进行统计学分析后,确定4个用药组眼压下降幅度差异都具有统计学意义(P<0.01)。在降低术后高眼压的应用中,单独使用β阻滞剂或α激动剂在疗效上无明显差异(P>0.05);与碳酸酐酶抑制剂合用时,β阻滞剂的降眼压效果优于α激动剂(P<0.05)。β阻滞剂与碳酸酐酶抑制剂的联合降眼压作用不仅优于单独使用β阻滞剂(P<0.05),更明显优于单独使用α激动剂(P<0.01)。结论在降低术后高眼压的药物治疗中,联合应用抗青光眼药物比单独应用疗效更显著。
Objective To compare the effects of three antiglacomatous agents on ocular hypertension after pars plana vitrectomy （PPV）. Methods One hundred and seventy-five patients aged 18 to 65 years, diagnosed with ocular hypertension after pars plana vitrectomy （PPV）, whose baseline intraoeular pressure （IOP） prior to and after surgery was （16.62±3.40）mmHg and （30.76±7.47）mmHg, were selected for this experiment. They were divided into 4 groups and each was supplied with 1 or 2 types of antiglaucomatous eye drops. Fifty-six patients in group 1 were treated with a beta-block er as monotherapy; 36 patients in group 2 were treated with an alpha- adrenergic agonist as monotherapy; 48 patients in group 3 were treated with a beta-blocker in conjunction with a carbonic anhydrase inhibitor （CAI）; 35 patients in group 4 were treated with an alpha-agonist, also in conjunction with CAI. All patients were monitored for a decrease in lOP after using eye drops for 3 days and 9 days. Results After using the eye drops for 3 days, the extent of the IOP decrease for group l was （9.87±5.16）mmHg; for grnup 2 was （7.87±6.00）mmHg, for group 3 was （13.03±8.43）mmHg and for group 4 was （9.48±6.42）mmHg. After using the eye drops for 9 days, the extent of the lOP decrease for group l was （13.16± 5.09）mmHg, for group 2 was {lO.61＋6.16）mmHg, for group 3 was （16.60±8.93）mmHg and for group 4 was （13.63＋7.96）mmHg. For all 4 groups, the effect on IOP was highly significant after using eye drops for 3 days and 9 days （P〈0.01）. Conclusion For decreasing ocular hypertension after PPV, when either a beta-blocker or alpha-agonist is used as monotherapy, there is very little difference in their effects. However, when either is used as adjunctive therapy in conjunction with CAI, the effect of a beta-blocker is better than an alpha-agonist alone. Furthermore, the effect nf a beta-blocker in conjunction with CAI is not only better than a beta-blocker alone as monotherapy, hut is als
出处
《眼视光学杂志》
2009年第4期306-308,共3页
Chinese Journal of Optometry & Ophthalmology
关键词
玻璃体切割术
眼压
Β阻滞剂
α激动剂
碳酸酐酶抑制剂
pars plana vitrectomy
intraocular pressure
beta- blocker
alpha-adrenergic agonist
carbonic anhydrase inhibitor
