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热应激对大鼠在体心肌缺血/再灌注性心律失常及抗氧化酶的影响 被引量：4

Effect of heat stress preconditioning on myocardial lschemia/reperfusion lnduced arrhythmia and antioxidative enzymes
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摘要 目的:探讨热应激对大鼠在体心肌缺血/再灌注性心律失常及抗氧化酶的影响。方法:大鼠热应激后,建立心肌缺血/再灌注损伤模型,观察大鼠在缺血5min、10min和再灌注10min、20min和30min后心律失常发生情况,动态Ⅱ导联心电图监测室性早搏(PVB)、室性心动过速(VT)及心室颤动与扑动(VF)的发生率和血中超氧化物歧化酶(SOD)活性、活性氧(ROS)及丙二醛(MDA)含量的变化。结果:热应激预处理后,缺血10min时,能明显改善PVB的发生率(P<0.01);可明显减少再灌注10min和20min时VT、VF(P<0.01)的发生率;能明显提高再灌注10min时血中SOD活性(P<0.01),降低MDA和ROS的含量(P<0.01)。结论:热应激预处理能明显降低大鼠在体心肌缺血/再灌注性心律失常的发生率,可提高血中SOD活性,降低MDA和ROS的含量。
作者 谭志鑫 廖艳华
机构地区 湖北民族学院医学院 湖北省建始县人民医院
出处 《中国应用生理学杂志》 CAS CSCD 北大核心 2009年第3期360-361,427,共3页 Chinese Journal of Applied Physiology
基金 湖北省卫生厅科研基金一般项目(JX3B74)
关键词 热应激预处理 缺血/再灌注 心律失常 抗氧化 heat stress preconditioning ischemia/reperfusion arrhythmia antioxidative
分类号 R605.971 [医药卫生—急诊医学]
  • 相关文献

参考文献5

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共引文献7

同被引文献45

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引证文献4

二级引证文献33

中国应用生理学杂志
2009年 第3期

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