摘要
目的:观察13-甲基肉豆蔻酸(13-MTD)对大鼠有无长期毒性作用,以评价13-MTD的安全性。方法:取SD大鼠80只,随机分为0.75、1.50、3.00g/kg3个剂量组和空白对照组,每组20只,雌雄各半。每天灌胃给药1次,连续给药12周后进行血液学、血液生化学、脏器指数和病理组织学检查,同时进行恢复性观察。结果:除高剂量组大鼠给药期间平均进食量较少、体重增长较慢外,各剂量组大鼠的一般情况、血常规、肝、肾功能、主要脏器指数及病理检查均无明显异常。停药2周后观察未见13-MTD延迟性不良反应。结论:13-MTD以3.00g/kg相当于临床拟用量150倍给予大鼠连续口服12周,无明显毒性反应。
Objective： To monitor any long-term toxicity reactions of 13-methyltetradecanoic acid （13-MTD） to rats, and evaluate the safety of 13-MTD Methods： 80 SD rats were randomly divided into 4 groups： 0.75, 1.50, 3.00 g/kg test groups and blank control group, with 20 rats in each group. The rats in three test groups were orally administered with 13-MTD for 12 weeks, then the blood routine, hepatorenal functions, major organ indexes and pathological biopsy were observed. Results： Except the relatively lower weight growth rate and less appetite in the highest dosage group, no significant abnor- mality of general condition, blood routine, hepatorenal functions, major organ indexes and pathological biopsy in other dose groups was observed. Conclusion： Oral administration of 13-MTD for 3.00 g/kg （150 times clinically recommended dose） daily for 12 weeks in rats is safe and has no obvious toxicity.
出处
《中国医药导报》
CAS
2009年第25期19-21,共3页
China Medical Herald
基金
福建省科技厅重大科技项目(99-Z-18)
关键词
抗肿瘤药
13-甲基肉豆蔻酸
长期毒性
大鼠
Antineoplastic agents
13-methyltetradecanoic acid
Long-term toxicity
Rats
