摘要
【目的】比较持续皮下胰岛素输注（CSⅡ）和多次胰岛素皮下注射（MSⅡ）在2型糖尿病强化降糖中的效果。【方法】60例新诊断2型糖尿病病人，分成胰岛素泵治疗组24例（CSⅡ组）和皮下注射胰岛素组36例（MSⅡ组），治疗2周，观察两组治疗前后空腹及餐后血糖、胰岛素、C肽变化，比较两组血糖达标天数、最大胰岛素用量、平均胰岛素用量及低血糖现象发生情况。【结果】治疗后两组血糖均有明显下降（P〈0．05），胰岛素及C肽水平较治疗前明显升高（P〈0．05），两组治疗后上述改变无明显统计学差异（P〉0．05）。但CSⅡ组血糖达标时间较MSⅡ组短，平均胰岛素用量及最大胰岛素用量均较MSⅡ组少，且低血糖发生次数也较MSⅡ组少，差异均有统计学意义（P〈0．05）。【结论】CSⅡ和MSⅡ两种治疗方法均可有效降低2型糖尿病患者血糖，改善胰岛β细胞分泌功能，对初发的2型糖尿病有良好治疗效果，其中胰岛素泵可以缩短血糖达标天数，减少胰岛素用量，降低低血糖发生率，有一定优势。
[Objective]To compare the therapeutic efficacy between continuous subcutaneous insulin infusion （CSⅡ） and multiple subcutaneous insulin injection （MSⅡ） in type 2 diabetes mellitus（T2DM）. [Meth- ods] Sixty patients with T2DM were randomly divided into CSⅡ group（n ：24） and MSⅡ group（n =36）. The changes of the values of fasting and postprandial plasma glucose, serum insulin, C peptide, the time of blood glucose control, the insulin administration dose and the average insulin dose and the rate of hypoglycemia were observed and compared at 2 weeks after treatment. [Results] The plasma glucose of two groups were obviously decreased, and the serum insulin and C peptide of two groups were obviously raised after treatment （ P〈0. 05）. There were no significant differences between the two groups （ P〉0.05）. But the time of blood glucose control, the insulin administration dose and the rate of hypoglycemia were different between the two groups （ P〈0.05）. [Conclusion]Both the methods （CSⅡ and MSⅡ） can effectively reduce the blood glucose and improve the beta-cell function, so they have efficacy in the treatment of newly diagnosed T2DM. CSⅡ can also reduce the time of reaching the target of blood glucose, and decrease the insulin dose and reduce the incidence rate of hypoglycemia.
出处
《医学临床研究》
CAS
2009年第8期1395-1397,共3页
Journal of Clinical Research
基金
本课题为广东省东莞市科技局立项课题（课题编号2007105150116）
