摘要
目的:了解丙型肝炎患者细胞免疫功能的变化及抗-HCV-IgM检测意义。方法:采用抗体致敏红细胞花环法和ELISA法对40例丙型肝炎患者T淋巴细胞亚群及抗-HCV-IgM进行检测。结果:急、慢性丙型肝炎患者均存在细胞免疫功能紊乱,以慢性丙型肝炎较明显,表现CD_8细胞上升,CD_4/CD_8下降。抗-HCV-IgM与细胞免疫功能和病毒复制状态有关,抗-HCV-IgM阳性者,CD_4、CD_4/CD_8较低,HCV-RNA阳性率较高。结论:丙型肝炎患者存在细胞免疫功能紊乱,其程度与丙型肝炎类型有关;抗-HCV-IgM检测可作为观察病毒复制的指标之一。
Objective: To study the variety of cellular immunity function and the significance of anti-HCV-IgM in patients of hepatitis C. Method: The T lymphocyte subsets and anti-HCV-IgM were detected by EA rosette and ELISA. Result: The function of cellular immunity was disorder in the patients of hepatitis C, especially in patients of chronic hepatitis C, CD8 was higher and CD4/CD8 was lower than that of normal control. Anti-HCV-IgM was related to the function of cellular immu-nity and the levels of viral replication. Conclusion: The degree of the disorder of cellular immunity in patients of hepatitis C was related to the type of hepatitis C; Anti-HCV-IgM was one of the index of observe the replication of hepatitis C virus.
出处
《河北医药》
CAS
1998年第4期193-194,共2页
Hebei Medical Journal
