摘要
目的：应用相应单克隆抗体探讨胃癌中雌激素受体（ＥＲ）和孕激素受体ＰＲ表达的临床意义。方法：用ＥＲ、ＰＲ单克隆抗体对１２０例胃癌标本进行免疫组化（ＡＢＣ法）染色。结果：（１）ＥＲ、ＰＲ在１２０例胃癌中阳性表达率分别为３２．５％、３０．８％；两者共同阳性３４例（２８．０％）；（２）ＥＰ、ＰＲ在胃癌Ｂｏｒｍａｎ第４型；胃低分化腺癌；粘液腺癌和有淋巴结转移组其阳性率显著高于其它各组（Ｐ＜０．０１）。而与患者年龄、性别无关（Ｐ＞０．０５）；（３）ＥＲ、ＰＲ共同阳性３４例中，２２例接受化疗加三苯氧胺治疗，１２例单用化疗，随访３年，两者生存率有明显差异（Ｐ＜０．０５）。结论：ＥＰ、ＰＲ阳性表达的胃癌是一种激素依赖性肿瘤，其预后较差，但对接受化疗加内分泌治疗有较好效果，可延长患者生存期。
Purpose: To study the clinical significance of the expression of ER (Estrogen receptor) and PR (Progestorone receptor) in gastric cancer. Method: Surgical specimens of 120 cases gastric cancer were stained using monoclonal antibody of ER and PR by the Avidin-Biotin peroxidase comlexs (ABC) immunohistochemistry method. Results: (1)The positive rates of expression for ER and PR were 32.5% and 30.8%, respective. and in 34 cases (28%) was for all the two elements; (2)The positive rates of ER and PR were significantly higher in Borrmann 4 as well as in poorly differentiated adenocarcinoma, mucinous adenocarcinoma and metastasis of lymph nodes than in the other groups (P<0.01). It is not related to age or esx. (P>0.05). (3)Tweny-two of 34 patients (64.7%) with positivity ER of and PR received adjuvant tamoxifen therapy and chemotherapy, follow-up for 3 years, survinal rates was very different between these two groups (P<0.05). Conclusions: ER and PR positive gastric cancer is a tumor of endocrine dependency. It has a poor prognosis but may be effectively treated by chemotherapy and endocrine therapy. The survival of these patients was prolonged.
出处
《癌症》
SCIE
CAS
CSCD
北大核心
1998年第4期268-270,共3页
Chinese Journal of Cancer
关键词
胃肿瘤
雌激素
孕激素
受体
基因表达
Gastric carcinoma estrogen receptors (ER) Progestin receptors (PR) Immunohischemistry
