期刊文献+

伊立替康肝动脉化疗栓塞联合5-Fu/CF静脉化疗治疗结直肠癌肝转移的临床观察 被引量:2

Clinical Study of TACE with Irinotecan and Lipiodol Combining with Intravenous Chemotherapy of CF/5-Fu in Treatment of Hepatic Metastasis from Colorectal Cancer
下载PDF
导出
摘要 目的评价伊立替康介入栓塞联合5-Fu/CF静脉化疗治疗结直肠癌肝转移的疗效和毒性。方法结直肠癌肝转移患者行TACE术,伊立替康(CPT-11)加超液化碘油化疗栓塞,介入完成后即行5-Fu/CF静脉化疗,每3周重复。结果全组26例患者共接受了98个周期化疗,平均4个周期(3~6周期)。CR2例(7.69%),PR8例(30.77%),SD13例(50%),PD3例(11.54%);临床获益率88.46%(23/26);中位疾病进展时间7.3月;中位生存期14.2月。最常见的毒副反应是中性粒细胞减少,消化道反应,多为Ⅰ~Ⅱ级。结论伊立替康肝动脉化疗栓塞联合CF/5-Fu静脉化疗治疗结直肠癌肝转移疗效肯定,毒性反应可以耐受。 Objective To evaluate the efficacy and toxicity of TACE using Irinotecan and lipiodol combining with intravenous CF/5-Fu in the treatment of hepatic metastasis from colorectal cancer. Methods Twenty six cases with hepatic metastasis from colorectal cancer were treated by the above-mentioned method, every three weeks was a cycle. Results Two cases had complete response, eight cases had partial response,thirteen cases had stable disease and three cases with progressive disease. Gross efficiency rate was 38. 46% and the stability rate was 50%. The clinical beneficial response rate was 88. 46%. Median time to progression was 7. 3 months and median overall survival time was 14. 2 months. The common treatment related adverse events were neutropenia and delayed diarrhea. Toxic effect was light. Conclusion TACE using Irinotecan and Lipiodol combining with intravenous CF/5-Fu in the treatment of hepatic metastasis from colorectal cancer is an effective and well tolerated regimen.
出处 《肿瘤防治研究》 CAS CSCD 北大核心 2009年第8期696-698,共3页 Cancer Research on Prevention and Treatment
关键词 伊立替康 肝转移癌 结直肠癌 介入 Irinotecan Hepatic metastasis Colorectal cancer Intervention
  • 相关文献

参考文献9

  • 1Adam R. Current surgical strategies for the treatment of colorect cancer liver metastases[J]. Eur J Cancer, 2004, 2(suppl) :21-26. 被引量:1
  • 2Saltz L B, Cox J V, Blank C, et al. Irinotecan plus fluorouracil and leucovorin for metastatic colorectal cancer[J]. N Engl J Med, 20(10,343 ( 13 ) :905-914. 被引量:1
  • 3钱羽,臧爱华.晚期转移性结直肠癌内科治疗进展[J].肿瘤防治研究,2008,35(1):70-73. 被引量:2
  • 4黄勇,秦叔逵,钱军,邵志坚,刘秀峰,廖世兵,龚新雷.伊立替康周疗法治疗转移性大肠癌的临床观察[J].肿瘤防治研究,2005,32(2):110-112. 被引量:6
  • 5庄潮平,蔡高阳,李廷汉,王永全,陈维荣.卡培他滨联合血管内皮抑素或依立替康治疗奥沙利铂耐药晚期结直肠癌[J].中国肿瘤生物治疗杂志,2009,16(2):175-180. 被引量:9
  • 6Oshowo A, Gillams AR, Lees W R, et al. Radiofrequency ablation extends the scope of surgery in colorectal liver metastasis [J]. Eur J Surg Oncol, 2003, 29(3):244-247. 被引量:1
  • 7Oshowo A, Gillams AR, Harrison E, et al. Comparison of resection and radiofrequerey ablation for treatment of solitary eolorectal liver metastases[J]. Br J Surg, 2003,90 (10), 1240- 1243. 被引量:1
  • 8Vogl TJ, Zangos S, Balzer JO, et al. Transarterial chemoembolization of liver metastases Indication technique results[J]. Rofo, 2002, 174(6):675-683. 被引量:1
  • 9Wasser K, Giebel F, Fischbach R, et al. Transarterial chemoembolization of liver metastases of colorectal carcinoma using degradable starch microspheres (spherex) : personal investigations and review of literature[J]. Radiologe, 2005, 45 (7): 633-643. 被引量:1

二级参考文献15

共引文献14

同被引文献29

二级引证文献4

相关作者

内容加载中请稍等...

相关机构

内容加载中请稍等...

相关主题

内容加载中请稍等...

浏览历史

内容加载中请稍等...
;
使用帮助 返回顶部