摘要
目的观察苦参注射液辅助选择性动脉栓塞化疗术(transcatheter arterial chemoembolization,TACE)联合全身化疗治疗结肠癌肝转移的疗效及毒副反应。方法 86例结肠癌肝转移患者,均给予TACE联合全身化疗,其中48例加用复方苦参注射液静脉滴注(苦参组)。比较苦参组与另38例TACE联合全身化疗(联合组)近期疗效及治疗后呕吐反应、腹痛、肝功能。结果术后2月,两组总有效率及疾病控制率比较,差异无统计学意义(P>0.05)。苦参组术后24小时呕吐及腹痛症状明显轻于联合组,术后1周谷丙转氨酶(ALT)和总胆红素(TB)明显优于联合组,差异均有统计学意义(P<0.05)。结论苦参静脉滴注可以明显减轻TACE全身化疗后的呕吐及腹痛,减轻TACE的肝脏毒副作用。
Objective To observe the clinical effect and toxicity of transcatheter arterial chemoembolization （TACE） and chemotherapy combined with sophora injection in the treatment of colorectal cancer liver metastasis. Methods Eight-six patients with colorectal cancer liver metastasis were all treated with TACE and chemotherapy. Of the patients ,48 cases were added with sophora injection （sophora group）. The recent curative effect, the vomiting reaction after treatment, abdominal pain and liver function in the sopho- ra group were compared to another 38 without sophora treatment. Results There was no significant difference in the total effective rate and the disease control rate after 2 months treatment between the two groups. Rate of vomiting and abdominal pain after 24 hours in the sophora group was significantly lighter than that in the control group, and ALT and TB in the sophora group was better than that in the control group after 2 weeks （ all P 〈 0.05 ）. Conclusion Sophora intravenous infusion can significantly reduce vomiting and abdominal pain caused by TACE and chemotherapy, and protects the liver lesion of TACE.
出处
《实用医院临床杂志》
2015年第5期158-160,共3页
Practical Journal of Clinical Medicine
基金
四川省卫生厅科研基金资助项目(编号:11ZB212)
关键词
苦参
结肠癌
肝转移
选择性动脉灌注化疗
全身化疗
Sophora
Colorectal carcinoma, Liver metastasis, Transcatheter arterial chemoembolization, Chemotherapy
