摘要
目的通过对股骨头缺血坏死的组织病理学观察,从而在组织病理学上阐述股骨头坏死的发病机制。方法收集行散关节置换手术的临床病例40例,其中20例为股骨头坏死作为病理组,另20例均为囊内骨折作为对照组。取股骨头坏死区及其周围区域骨组织各1块,对照组取相应部位骨组织。应用苏木素-伊红染色技术光镜下观察股骨头骨组织中股骨头缺血坏死的基本病理变化。结果病理组股骨头骨组织中骨细胞发生了坏死、崩解,细胞核固缩、破裂。骨细胞所在的骨陷窝变空,环骨板变得紊乱,部分骨板发生了溶解,有少量新骨形成。周围组织充血,有淋巴细胞和浆细胞浸润,出现大量纤维组织增生和肉芽组织增生。对照组股骨头环骨板呈平行排列,层次多而整齐,骨陷窝位于骨板间或骨板内,单个分散排列,呈椭圆形蓝紫色,其内含有骨细胞。未见骨坏死区域以及肉芽组织或纤维组织。结论坏死股骨头内的肉芽组织和纤维组织的增生是股骨头坏死的重要病理变化,在股骨头坏死的发生发展中起有重要作用。
[Objective] In order to elucidate the pathogenesis of ANFH at the level of molecular pathology through observation of the histopathologic ANFH. [Methods] The specimens were 40 femoral heads from patients undergoing total hip replacement including 20 cases of ANFH （pathology group） and 20 eases of the femoral head fracture under the capsule （control group）. We coolleeted the spicemens from the sites of bone necrosis and neighborhood in the femoral heads, and the specimens for control group correspondent to pathology group. Observed the basic pathologic changes of ANFH under light microscope stained by HE. [Results] Histopathologic observation ：we found bone cells manifested necrosis collapse and karyopyknosis in pathological group. The bone lacunas were hollow, the circumferential lamelia turned turbulent and a part of them dissolved. A few new bone can be seen around dead bone in the feromal heads, congestion of the tissue around the necrotic bone and infiltration of lymphatic celia and plasma cells are observed, and there are proliferation of fibrous tissue and granulomatous tissue in the gross hap. In control group,circunfferential lamella were excessive and parallell in the order.Bone lacunas locate in the bone lamella or among them, single and separately, stained by blue-purple. Bone cell lies in lacuna. No necrosis and granulation tissues or fibrous tissues can be found in controL[Conclusion] The proliferation of granulomatous tisssue sand fibrous tissues have significant pathologic changes in the necrotic femoral head and palys an important role in the development of the necrosis of femoral head.
出处
《中国现代医学杂志》
CAS
CSCD
北大核心
2009年第13期2044-2047,共4页
China Journal of Modern Medicine
关键词
成人
股骨头
缺血坏死
组织病理学
adult
femoral head
avascular
neerosis
histopatbology
