摘要
对风湿骨康片、骨刺消痛胶囊和消痛灵酊3种中成药中的乌头生物碱提取分离后,进行基质辅助激光解吸电离-飞行时间质谱和电喷雾-四极杆飞行时间串联质谱分析.发现在这3种中成药中含有双酯型生物碱、其水解产物单酯生物碱以及尼奥灵类生物碱等11种生物碱.苯甲酰中乌头原碱是前两类口服药中的主要生物碱成分,而消痛灵酊中则以次乌头碱为主.
Matrix-assisted laser desorption/ionization time-of-flight mass spectrometry was used for the analysis of the aconitum alkaloids in three kinds of proprietary Chinese medicines including Fengshi-Gutong-Pian （ FSGTP）, Guci-Xiaotong-Jiaonang （GCXTJN） and Shexiang-Zhuifeng-Gao （SXFSG）. As many as 11 kinds of aconitum al- kaloids including diester-diterpenoid alklaoids, monoester- diterpenoid alaklaoids and neoline-type alkaloids were detected in these Medicines. Benzoylmesaeonine is the main alkaloid component in FSGTP and GCXTJN, however, benzovlaconine and mesaconitine become the dominant alkaloids in SXFSG.
出处
《深圳大学学报（理工版）》
EI
CAS
北大核心
2009年第3期257-261,共5页
Journal of Shenzhen University(Science and Engineering)
基金
深圳市科技计划资助项目(200528)
关键词
制草乌
制川乌
基质辅助液充解吸电离-飞行时间
乌头碱
生物碱
中药质谱法分析
Radix Aconiti Preparata
Radix Aconiti Kusnezoffii
matrix-assisted laser desorption/ionization time-of-flight （MALDI-TOF）
Aconitine
alkaloid
mass spectrometry analysis of traditional Chinese medicine
