摘要
目的:了解我院药品不良反应(ADR)发生规律和特点,为临床提供药品安全性信息。方法:对我院2008年上报的74份ADR报告,按患者年龄、性别、给药途径、引起ADR的药品种类、涉及器官或系统以及临床表现等进行统计、分析。结果:静脉滴注较其它给药途径更易发生ADR(57例,占77.03%);抗微生物药引发ADR的比例最高(39例,占52.70%);74例报告中,男女性别比例无明显差异,10岁以下和60岁以上患者ADR发生率高于其他年龄段;ADR的临床表现以皮疹、瘙痒等皮肤及其附件损害为主,其次为心血管系统以及消化系统损害。结论:抗微生物药是不良反应监测的重点,提高临床安全用药意识,应加强药品不良反应监测,确保用药安全。
OBJECTIVE：To study the regularity and characteristics of adverse drug reactions（ADR） occurred in our hospital,to provide drug safety information.METHODS：74 ADR case reports collected in our hospital in 2008 were analyzed statistically in respect of patients＇ age and sex,route of administration,category of the drugs,organs and systems involved,and clinical manifestation of the ADR.RESULTS：The ADR were more likely caused via intravenous drip（57cases,77.03%）;anti-infective shad the highest proportion to induce ADR（39cases,52.70%）;of the total 184 ADR cases,no significant difference was noted in sex,but the incidence rate of ADR inpatients aged below 10 or above 60 was higher than in other age groups.Of which,levofloxac in dominated the first place.The main presentation of the ADR was damage of skin and its appendages such as erythra and pruritus etc,followed by the lesions of digestive system and circulatory system.CONCLUSION：An emphasis should be laid on the ADR of antimicrobial drugs.It is important to improve people＇s awareness of drug safety,strengthen ADR monitoring and ensure safe medication.
出处
《中国医院用药评价与分析》
2009年第7期554-556,共3页
Evaluation and Analysis of Drug-use in Hospitals of China
