摘要
目的探讨广州地区儿童真菌感染的病原分布特点及其耐药状况,为防治儿童真菌感染提供实验室依据。方法对患儿感染部位的真菌进行分离培养和鉴定;以ATBTMFUNGUS3酵母样真菌药敏试验条进行常用抗真菌药物的敏感性分析。结果从患儿标本中分离出558株真菌,主要来自呼吸道有299株,占53.58%;其次是消化道、伤口(创口)、泌尿系统和血液等,分别占28.14%、6.27%、4.66%、3.76%。其中白色假丝酵母菌367株,占65.77%;其次为热带假丝酵母菌、光滑假丝酵母菌、近平滑假丝酵母菌、克柔假丝酵母菌、季也蒙假丝酵母菌等,分别占15.28%、5.02%、4.48%、3.41%、2.69%。从骨髓中检出5株马尔尼菲青霉,从脑脊液中检出3株新型隐球菌。真菌对两性霉素B、5-氟胞嘧啶、氟康唑、伊曲康唑、伏立康唑等总耐药率分别为8.78%、4.84%、10.54%、1.36%、0.85%。结论引起儿童真菌感染的主要病原菌是白色假丝酵母菌,对真菌感染应该有针对性地使用高效的抗真菌药物进行早期治疗。
Objective To investigate the characteristics of pathogen distribution and drug resistance in pediatric fungal infection. Methods The fungi were identified by VITEK2-Compact verification and the drug sensitive experiments were done by ATB^TM FUNGUS 3 trial. Results There were 558 fungal strains in all samples. The major infection site was respiratory tract （299 cases, 53.58%）; infection rates in intestinal tract, wound, urinary tract and blood were 28.14%, 6.27%, 4.66% and 3.76%, respectively. The most common infection pathogen was Candida albicans （ 367strains, 65.77% ）, infection rates with Candida tropicalis, Candida glabrata, Candida parapsilosis, Candida kruse and Candida guilliermondii were 15.28%, 5.02%, 4.48%, 3.41% and 2.69%, respectively. These anti-fungus medicine resistance of 558 fungal strains to amphotenicin B （AMB）, 5-flucytosine （SFC）, fluconazole （FCA）, itraconazole（IRT） and voriconazole （VRC） were 8.78%, 4.84%, 10.54%, 1.36% and 0.85%, respectively. Conclusion Candida albicans was the most important pathogen in pediatric fungal infection. The key of successful treatment was maintaining high alertness and identifying mycosis at an early stage.
出处
《热带医学杂志》
CAS
2009年第7期772-773,798,共3页
Journal of Tropical Medicine
关键词
真菌
感染
耐药性
儿童
fungus
infection
resistance
children
