摘要
目的:观察七箭方提取物对大鼠糖尿病肾病的影响,并比较其与七箭方饮片疗效的不同。方法:选择雄性SD大鼠予链脲佐菌素65mg/kg单次腹腔注射诱发糖尿病,观察糖尿病大鼠灌服不同剂量七箭方提取物、七箭方饮片、卡托普利90天后,血糖、血脂、肾功能、肾指数、肾小球滤过率、肾脏病理的改变。结果:糖尿病大鼠灌服七箭方提取物后,血糖、血脂、肾功能、肾指数、肾脏病理明显改善(P<0.05或P<0.01),疗效优于七箭方饮片。结论:七箭方提取物对糖尿病肾病的疗效优于饮片。
ObjectiVe： To study the protective effect of Qijian formula extract on renal function of rats with diabetic nephropathy and compare its curative effect with effect of cut crude drug. Methods： Diabetes mellitus was induced in male SD rats by intraperitoneal injection of streptozotocin （65 mg/kg）. Blood serum glucose,t riglyeride,cholesterol,renal function,renal index,pathological index of diabetic rats were detected after Qijian formula extract,cut crude drug,captopril were administered. Results： Blood serum glueose,triglyeride,cholester ol,renal function,renal index,path-ological index of diabetic rats in Qijian formula extract group were obviously improved （ P〈0.05 or P〈0.01 ）, curative effect of cut crude drug was slightly worse. Conclusion： Curative effect of Qijian formula ex.tract on diabetic nephropathy is better than cut crude drug.
出处
《辽宁中医药大学学报》
CAS
2009年第8期244-245,共2页
Journal of Liaoning University of Traditional Chinese Medicine
关键词
糖尿病肾病
七箭方
药效研究
diabetic nephropathy
Qijian formula extract
pharmaceutical Reasearch
