摘要
目的探讨淋巴管特异标记物D2-40在直肠癌淋巴管浸润检测中的价值及临床意义。方法采用单克隆抗体D2-40检测128例直肠癌淋巴管浸润情况,与常规HE染色对比,并分析其与直肠癌临床病理参数的关系。结果D2-40标记显示128例中有51例淋巴管浸润;HE染色显示18例淋巴管浸润。大体浸润型组、低分化组、浸润至浆膜外组的直肠癌淋巴管浸润的检测率明显高于HE染色对应组。结论特异性检测肿瘤淋巴管浸润D2-40抗体较HE染色更敏感,且浸润程度与分化程度、浸润深度和大体类型密切相关,因此具有明显临床病理应用价值。
Objective To investigate the lymphatic invasion of rectal cancer by using D2 - 40, a marker of lymphatic eno dothelium,and its clinicopathological signicance. Methods Monoclonal antibody D2 - 40 and routine HE staining were used to detect the lymphatic invasion in 128 patients with rectal cancer, and the relationship between lymphatic invasion and clinicopathological findings were analyzed. Results 51 of 128 cases were found with lymphatic invasion by using D2 -40, whereas only 18 cases were found when using HE staining. Lymph node metastasis degree in rectal cancer was closely correlated with differentiation,infiltration depth and types of tumor. Conclusion D2 -40 is more sensitive than HE staining in detecting lymph node involvement. Lower differentiation ,invasion depth and gross pathological types were related to lymph node invasion.
出处
《实用癌症杂志》
2009年第2期148-149,共2页
The Practical Journal of Cancer
关键词
直肠癌
淋巴管浸润
Rectal cancer
Lymphatic invasion
