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血管生成抑制剂Canstatin联合豆蔻提取物治疗荷瘤裸鼠实验研究 被引量:3

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摘要 目的:探讨canstatin联合豆蔻提取物对人胃癌细胞株SGC-7901胃癌模型裸鼠肿瘤生长的影响。方法:建立裸鼠原位移植人胃癌模型,将模型裸鼠随机分为Canstatin组、豆蔻提取物组、联合用药组,同时设立对照组,对原位种植胃癌的体积和抑瘤率、肿瘤微血管密度进行观察,行凋亡指数检测。结果:豆蔻提取物组、Canstatin组、联合用药组的抑瘤率分别为28.8%、38.9%、44.1%;豆蔻提取物组、Canstatin组、联合用药组、对照组的肿瘤微血管密度(MVD)分别为23.81±8.15、21.50±9.17、19.01±7.15、29.45±6.72。结论:豆蔻提取物与Canstatin均可以抑制荷瘤裸鼠移植瘤的生长,促进移植瘤细胞的凋亡,降低肿瘤微血管密度,但以联合作用效果显著。
作者 陈平 孙振华
出处 《浙江中西医结合杂志》 2009年第8期484-485,共2页 Zhejiang Journal of Integrated Traditional Chinese and Western Medicine
基金 江苏省卫生厅科研课题(No.H200554)
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参考文献5

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