摘要
目的探讨抗内皮细胞抗体（AECA）和抗整合素αvβ3抗体测定在鉴别特发性血小板减少性紫癜（ITP）和系统性红斑狼疮（SLE）中的临床意义。方法用EL1SA法分别测定40例ITP患者，43例SLE患者及44名正常人血清中的AECA和抗整合素αvβ3抗体水平。结果SLE组、ITP组患者血清AECA、抗整合素αvβ3抗体水平明显高于正常对照组（P〈0．01）SLE组患者血清AECA、抗整合素αvβ3抗体水平及阳性率显著高于ITP组（P〈0．01）。结论血清AECA和抗整合素αvβ3抗体的测定在鉴别诊断ITP和SLE中有显著的临床意义。
Objective To study the clinical significance of determining serum anti-endothelial cell antibodies （AECA） and anti-integrin αvβ3 antibodies in the differential diagnosis of idiopathic thrombocytopenic purpura （ITP） and systemic lupus erythematosus （SLE）.Methods Serum AECA and anti-integrin αvβ3 antibodies in 40 patients with ITP,43 patients with SLE and 44 normal individuals were detected by ELISA method.Results The level of AECA and anti-integrin αvβ3 antibodies in patients with ITP and SLE was much higher than that in the normal group （P〈0.01）,the level and positive rate of AECA and anti-integrin αvβ3 antibodies in patients with SLE were much higher than that in ITP （P〈0.01）.Conelusion Detecting AECA and anti-integrin αvβ3 antibodies might be helpful for differential diagnosis of ITP and SLE.
出处
《中国血液流变学杂志》
CAS
2009年第2期227-229,共3页
Chinese Journal of Hemorheology
