摘要
目的:了解Wilson病(Wilson's disease,WD)患者的动态心电图异常情况,并分析其发生机制。方法:对30例WD患者的动态心电图特征进行观察分析。结果:WD患者动态心电图主要表现为活动时窦性心动过速(窦速)和休息时窦性心动过缓(窦缓)、偶发房性期前收缩(房早)和室性期前收缩(室早)、房性心动过速、室性心动过速及窦房传导阻滞等,个别心电图异常明显者为病程长且驱铜治疗不正规、神经系统症状严重者。结论:WD患者的动态心电图存在较多异常改变,其发生机制主要为铜在中枢神经系统沉积所致中枢性自主神经功能障碍,铜在心肌沉积所致心肌损害或肝硬化所致代谢性心脏损害。
Objective： To evaluate the various dynamic electrocardiogram （DCG） changes in patients with Wilson＇s disease （WD）. Methods： The DCG of 30 WD patients were systematically analyzed by professional observer after excluding other causes that could induce DCG abnormalities. Results： DCG in WD patients showed such abnormalities as sinus tachyeardia, sinus bradycardia, atrial or ventricular premature contraction, auricular tachycardia, ventricular tachycardia, sinoatrial block and et al. Severe DCG abnormalities were found in patients with long duration of illness, irregular decoppering treatment and severe neurological impairment. Conclusion： DCG abnormalities are not uncommon in WD and are presumably related to an underlying cardiomyopathy due to deposition of copper in heart, at the same time copper depositionin diencephalon, hypothalamus and brainstem nuclei and severe liver damage may underlie this.
出处
《安徽中医学院学报》
CAS
2009年第4期22-24,共3页
Journal of Anhui Traditional Chinese Medical College
关键词
WILSON病
动态心电图
心电图
Wilson＇s disease
Dynamic electrocardiogram
Electrocardiogram
