摘要
目的:了解我院严重药品不良反应(ADR)发生的情况和特点,以促进合理用药。方法:对我院2008年收集到的29例严重ADR报告,按ADR因果关系判断标准进行分析、评价。结果:29例严重ADR涉及药品22种,引起ADR例/次最多的是抗感染药,共9种;其次是内分泌系统和心血管系统药物。ADR涉及的器官或系统主要为皮肤及其附件,发现1例新的严重的ADR。结论:严重ADR的发生与多种因素有关,应增强合理用药意识,以减少和避免严重ADR的发生,保证药物治疗安全、有效。
Objective： To investigate the situation and characteristics of serious adverse drug reactions （ADR） occurred in our hospital in order to promote rational clinical drug use. Method： Twenty-nine severe ADR cases collected in our hospital in 2008 were analyzed statistically and evaluated based on the ADR causality judgment criteria. Result： All the severe ADR cases were associated with 22 kinds of drugs, the highest proportion was token by 9 kinds of anti-infective drugs, followed by endocrine drugs and cardiovascular drugs. The lesions of skin and its accessories were the predominant presentation of ADR. One case of new and severe ADR was found. Conclusion ： Severe ADR may he induced by many factors, therefore, it is necessary to strengthen the awareness of rational drug use to guard against severe ADR and ensure safe and effective medication.
出处
《药学与临床研究》
2009年第4期338-340,共3页
Pharmaceutical and Clinical Research
