摘要
目的研究大鼠静脉给予阿霉素(ADM)对去甲斑蝥素(NCTD)体内药物动力学的影响。方法用HPLC-MS方法测定ADM和NCTD合并给药与NCTD单独给药大鼠血浆中的NCTD浓度,比较两者的药动学参数。结果ADM和NCTD合并给药组与NCTD单独给药组相比在分布速度常数(α)、分布相半衰期(t1/2α)、中央室向周边室的转运速度常数(k12)3个药动学参数有统计学差异(P<0.05),其余药动学参数之间无显著差异(P>0.05)。结论NCTD与ADM合用时,ADM不会显著影响NCTD在大鼠体内的药动学过程,两药合用增效的原因主要在于药效学上的协同作用。
Objective To determine the effect of adriamycin on the pharmacokinetics of norcantharidin in rats. Methods Rats were divided into 2 groups： One group was treated with norcantharidin and the other with norcantharidin and adriamycin. Norcantharidin concentration in the two groups was detected by HPLC-MS, The pharmacokinetic parameters were statistically compared. Results The 3 pharmacokinetic parameters （α,t1 2（α） and k12） showed significant difference between the two groups （P〉0.05）, Conclusion Adriamycin has no significant effect on the pharmacokinetics of norcantharidin in rats. Enhanced efficiency of the two drugs in combination is mainly due to the synergism of pharmacodynamics.
出处
《中南药学》
CAS
2009年第7期502-506,共5页
Central South Pharmacy
