摘要
为改善聚乳酸的亲水性,采用自制的OH-PLA-OH和CAC为原料,制备Cl-PLA-Cl,以此作为大分子引发剂、以CuBr/2,2’-联吡啶为催化体系进行NVP的ATRP,制备三嵌段共聚物PVP-b-PLA-b-PVP.研究了制备PVP-b-PLA-b-PVP的最佳反应物用量及共聚物的亲水性与降解性能.结果表明,反应物料的最佳用量为Cl-PLA-Cl 4.17 g,NVP 11.12 g,CuBr0.29 g,2,2’-联吡啶0.62 g,环己酮30 mL.PVP-b-PLA-b-PVP的亲水性较PLA有明显提高.共聚物在NaOH溶液中的降解速率最快,磷酸盐缓冲液中最慢.该方法是改善聚乳酸亲水性的一条较好的途径.
Novel hydrophilic tri-block copolymers of poly-N-vinylpyrrolidone and polylactide were synthesized by ATRP using Nvinylpyrrolidone as the monomer and polylactideterminated with chlorides as the functional macroinitiator, which was prepared by reacting the hydroxyls-terminated polylactide oligomer with chloroacetic chloride in the presence of CuBr/2, 2＇-bipyridine as catalyst. The hydrophilicity and the degradability of the copolyrner films were investigated. The results showed that the hydrophilicity of the copolymer was much higher than that of PLA homo-polymer. The target copolymers PVP-b-PLA-b-PVP was degraded more rapidly than PLA. The degradation of copolymer in NaOH solution was more rapidly than in HCI solution, H2O and phosphate buffer solution. This method was a good way to improve PLA＇s hydrophilicity.
出处
《西安工业大学学报》
CAS
2009年第3期249-252,共4页
Journal of Xi’an Technological University
基金
西安工业大学校长基金(XAGDXJJ0809)
关键词
原子转移自由基聚合
聚乳酸
聚乙烯吡咯烷酮
亲水性
降解性
atom transfer radical polymerization
polylactic acid
poly- N- vinylpyrrolidone
hydrophilicity
degradability
