摘要
目的:评估二十八烷醇在提高高原军事作业劳动能力中的作用。方法:选择驻3700 m高原1年以上的健康男性青年38名,采用双盲法随机分为实验组和对照组,各19名。实验组口服二十八烷醇胶囊(10 mg,1次/d),连续服用30 d;对照组服用安慰剂胶囊(淀粉10 mg,1次/d),连续服用30 d。分别于服药前后测定受试者血红蛋白浓度,以及踏车运动前后的心率和血氧饱和度。结果:服用二十八烷醇1个月后,受试者静息和踏车运动心率显著降低,血红蛋白浓度减少,90 W踏车运动血氧饱和度明显升高,而对照组无此变化。结论:二十八烷醇能增强高原劳动能力,降低高原缺氧所致红细胞增多。
Objective：To evaluate the effects of octacosanol on military operation capacity at high altitude. Methods：38 male healthy adults who had lived at high altitude above sea level 3700 m for over one year were randomly divided into two groups（ n = 19 ）. Members in experimental group were treated with oral octacosanol capsule（ 10 rag,once a day） for 30 days,while those in control group took equal dose of placebo （starch） once a day for 30 days. Hemoglobin concentration before and after treatment in two groups were examined, respectively. Heart rate and oxygen saturation during the rest and exercise of three - graded treadmill test were also measured before and after treatment, respectively. Results： In experimental group, heart rate whether during the rest or exercise test and blood hemoglobin concentration decreased significantly, but their oxygen saturation at exercise load of 90 W increased after one - month treatment. However, no significant above - mentioned changes were observed in control group. Condusion：Octacosanol can improve physical work capacity and decrease polycythemia caused by hypoxia at high altitude.
出处
《西南国防医药》
CAS
2009年第7期670-671,共2页
Medical Journal of National Defending Forces in Southwest China
基金
军队"十一五"专项课题(06Z037)
关键词
高原
二十八烷醇
缺氧
劳动能力
血氧饱和度
血红蛋白
high altitude
octacosanol
hypoxia
physical work capacity
oxygen saturation
hemoglobin
