摘要
目的探讨急性心肌梗死患者发病6 h内C反应蛋白水平对经皮冠状动脉介入治疗预后的预测意义。方法测定84例急性心肌梗死患者发病6 h内血浆C反应蛋白水平,将患者分为C反应蛋白升高组(>5 mg/L)和C反应蛋白正常组(<5 mg/L)。所有患者均予经皮冠状动脉介入治疗。比较两组一般临床资料、既往病史、冠状动脉病变情况等因素,随访记录心脏不良事件(再狭窄、同一部位再梗死、再发心绞痛、心功能衰竭和心源性猝死)的发生情况。结果C反应蛋白升高组患者C反应蛋白水平和C反应蛋白峰值均高于C反应蛋白正常组,差异有统计学意义(P<0.05);C反应蛋白升高组患者发生冠状动脉病变支数多于C反应蛋白正常组,差异有统计学意义(P<0.05);C反应蛋白升高组患者随访期间心脏不良事件发生率为25.9%(7/27),明显高于C反应蛋白正常组(9.3%,5/54),差异有统计学意义(P<0.05)。结论急性心肌梗死发病6 h内C反应蛋白水平可作为预测经皮冠状动脉介入治疗预后的指标之一。
Aim To investigate the significance of C reactive protein （CRP） in predicting the prognosis after percutaneous coronary intervention （ PCI ） within 6 hours after attack of acute myocardial infarction （ AMI ）. Methods The CRP levels in plasma was detected in 84 AMI patients within 6 hours after attack, and the patients were divided into increased CRP group （ CRP concentration 〉 5 mg/L） and normal CRP group （ CRP concentration 〈 5 mg/L）. All of the cases underwent PCI. The factors of common clinical data, past medical history, pathological changes of coronary artery were compared between the two groups, and the kak-incident occurrences of heart, for example restenosis, re-infarction in the same position, recurrent angina pectoris, heart failure and cardiogenic sudden death were observed by following-up. Results The CRP levels and the peak value in the increased CRP group were significantly higher than those in the nor- mal CRP group, and there were significant difference between two groups （ P 〈 0.05 ）. The quantities of coronary artery in the increased CRP group were more than those in the normal CRP group, and the incidence rate of kak-incident of heart in the increased CRP group was 25.9% （7/27）, which was higher than 9.3% （5/54）in the normal CRP group （P 〈 0. 05 ）. Conclusion The CRP levels within 6 hours after attack of AMI can be taken as one of the indexes to predict the prognosis of PCI.
出处
《中国动脉硬化杂志》
CAS
CSCD
北大核心
2009年第5期406-408,共3页
Chinese Journal of Arteriosclerosis
关键词
急性心肌梗死
C反应蛋白
经皮冠状动脉介入治疗
预后
Acute Myocardial Infarction
C Reactive Protein
Percutaneous Coronary Intervention
Prognosis
