摘要
目的探讨血清白细胞介素-6(IL-6)和肿瘤坏死因子(TNF-α)浓度的测定在病毒性肝炎患者中的意义。方法采用放射免疫分析法分别检测健康对照组和病毒性肝炎组血清IL-6和TNFα-的浓度,并分别检测其HBV DNA含量。结果病毒性肝炎患者的IL-6和TNF-α的浓度水平显著高于健康对照组,差异有统计学意义(P<0.01);肝炎后肝硬化组显著高于慢性乙型肝炎组,差异有统计学意义(P<0.01);HBV DNA阳性组显著高于HBV DNA阴性组,差异有统计学意义(P<0.01)。结论血清IL-6和TNFα-的测定对病毒性肝炎患者机体的免疫损伤状况进行有效的反映,对判断患者病情预测和预后有一定的现实意义。
Objective To explore the significance of serum IL-6 and TNF-α concentrations in patients with hepatitis. Methods To detect and measure, by radiommunassay（RIA）, the concentrations of the serum IL-6 and TNF-α and their HBV DNA of the normal control group and the group with hepatitis. Results The concentrations of IL 6 and TNF of the patients with heptitis were significantly higher than those of the control group（P〈0.01）, and liver cirrhosis group was significantly higher than that of chronic hepatitis B group（P〈0.01）, HBV DNA positive group was significantly higher than that of HBV DNA negative（P〈0.01）. Conclusion The detect to the serum IL- 6 and TNF α is able to reflect effectively on the immune status of the patients with hepatitis and has some practical significance in judging and predicting the prognosis of the patients.
出处
《检验医学与临床》
CAS
2009年第14期1157-1158,共2页
Laboratory Medicine and Clinic
