摘要
目的探讨细胞骨架蛋白Ezrin在胃癌、癌前病变中的表达与Hp感染关系,及其在胃癌发生发展中可能的机制。方法采用免疫组化方法检测49例胃癌及癌前病变组织及16例正常胃黏膜标本中Ezrin蛋白的表达情况,并用快速尿素酶试验或Warthin-Starry胃螺旋染色法检测幽门螺杆菌(Hp)感染。结果胃癌及癌前病变组织Hp感染率显著高于正常组织(P<0.01);Ezrin蛋白表达在正常胃组织、癌前病变组织和胃癌组织中呈递减趋势,三者比较差异有统计学意义(P均<0.05);胃癌组织及癌前病变组织中Hp感染阳性组Ezrin蛋白的表达显著低于阴性组(P<0.05)。结论在胃黏膜癌变过程中,Ezrin蛋白表达逐渐下调,Ezrin蛋白表达与Hp感染相关,提示Hp感染可通过影响Ezrin蛋白表达,在胃癌的发生发展过程中发挥一定作用。
Objective To investigate on the relationship between infection of Helicobacter pylorl and expression of ezrin proteins in gastric carcinoma , to explore the mechanism of gastric carcinoma. Methods Forty nine pathologically confirmed and surgically resected gastric carcinoma samples, forty-nine precancerous carcinoma tissue samples, and sixteen normal tissue samples were chosen. The expression of ezrin were examined by immunohistochmical method. Rapid urease test and Warthin-Starry method detected infection of Hp. Results The infection rates of Hp in the group of gastric carcino- ma and gastric precancerous carcinoma lesion were significantly higher than that in the normal lesion（ P 〈 0.01 ）. The expression of ezrin protein decreased from the group of the normal lesion,gastric preeaneereus carcinoma, to gastrie carcinoma, the expression ezrin protein in three groups had statistical significance （ P 〈 0.05） ; The expression of ezfin protein in Hp positive gastric carcinoma, gastric preeancerous carcinoma lesion were obviously higher than that in Hp negative ones （ P 〈 0.05）. Conclusions Hp infection is closely related to the expression of ezrin protein in precancerous gastric and gastric carcinoma. The expression of ezrin proteins is playing a syncrgie role in the oceurrenee of gastric carcinoma.
出处
《山东医药》
CAS
北大核心
2009年第25期14-16,共3页
Shandong Medical Journal
关键词
胃肿瘤
癌前病变
EZRIN
幽门螺杆菌
免疫组织化学
stomach neoplasms
gastric precancerous carcinoma
Ezrin
helicobacter pylori
immunohistochemistry
