摘要
目的：探讨川芎嗪对肾缺血再灌注损伤的保护作用。方法：选用大鼠一侧肾切除，对侧肾缺血６０分钟动物模型，观察再灌注前、再灌注后２４小时肾组织中丙二醛（ＭＤＡ）含量及Ｎａ＋，Ｋ＋－ＡＴＰａｓｅ活力的改变以及使用超氧化物歧化酶（ＳＯＤ）和川芎嗪治疗对它们的影响。结果：６０分钟肾缺血和再灌注导致肾皮质ＭＤＡ含量显著增高，而Ｎａ＋，Ｋ＋－ＡＴＰａｓｅ活力明显降低，用ＳＯＤ和川芎嗪治疗后，肾皮质ＭＤＡ含量明显低于缺血组（Ｐ值分别＜０．０１和０．０５），Ｎａ＋，Ｋ＋－ＡＴＰａｓｅ活力则高于缺血组（Ｐ值均＜０．０５）。结论：川芎嗪通过抗氧化作用干扰氧自由基对肾组织的损伤。
To evaluate the protective role of Ligustrazine in ischemia and reperfusion injury. Methods The rat renal ischemia model with right nephrectomy and occlusion of the left renal pedicle for 60 minutes was used in this experiment. The changes of the renal cortical malondialdebyde (MDA) and Na+,K+-ATPase and the effects of superoxide dismutase (SOD)and Ligustrazine on them were studied at the time of 24 hour reperfusion after 60 minutes renal ischemia.Results Ischemia and reperfusion cause anincrease in MDA production and a reduction in Na+,K+- ATPase activity. These effects were prevented to various degrees by SOD as well as Ligustrazine.Conclusion Ligustrazine may act as an antioxidant to protect the renal tissue from free radical demage.
出处
《镇江医学院学报》
1998年第2期147-148,150,共3页
Journal of Zhenjiang Medical College
