摘要
布鲁氏菌病是威胁人类健康和畜牧业发展的重要的传染病,同时也是一种生物武器,是世界性的公共卫生问题。以双向凝胶电泳、生物质谱及生物信息学为主要技术支撑的蛋白质组学研究技术的完善进步,蛋白质组学研究将不断深入发展。近年来,蛋白质组学研究技术已应用到布鲁氏菌病研究领域中,在医学研究领域中不仅能为阐明布鲁氏菌活动规律提供理论基础,也能为探讨布鲁氏菌病的致病机理、疾病诊断、疾病防治和新型疫苗的研制等提供重要的理论依据和实际解决途径,从而为布鲁氏菌病的研究做出重大贡献。
Brucellosis is an important infectious disease which threatens human health and the development of animal husbandry, as well as a kind of biological weapon, which should be regarded as a worldwide public health problem. With the development of the research techniques of proteomics, which is technically supported by two dimensional gel electrophoresis, biological mass spectrogram, and bioinformatics, the research of proteome will further develop into a higher level. Recently, the proteomics research technique has been applied in the field of brucellosis study. This technique will not only establish theoretical basis for the study of regular pattern of brncella activity, but also provide important practical directions for the study on brucella＇ s pathogenesis, diagnosis, disease control and vaccine development, which greatly contribute to the research of brucellosis.
出处
《疾病监测》
CAS
2009年第5期373-378,共6页
Disease Surveillance
基金
863课题:布鲁氏菌快速诊断技术标志性抗原研究(No.2007AA02Z410)
