摘要
在碱性条件下，以氧气作为氧化剂，氯化铜和氯化钴作为催化剂，甲醇作为溶剂进行了对甲酚液相氧化，高选择性得到对羟基苯甲醛。再通过在氯仿中进行单溴化反应，在甲醇中以氯化亚铜和ＤＭＦ催化进行甲氧基化反应得到香兰素。这种高效制备方法总收率达６２．４％．
? The liguid phase oxidation of p cresol by oxygen under alkaline condition using copper chloride and cobaltous chloride as catalysts and methanol as solvent,has been performed with a view to afford the correspending aldehyde with sufficiently high selectivity.The cuprous chloride and DMF catalyzed exchange of bromine by methoxide in 3 bromo 4 hydroxybenzaldehyde,which was obtained by monobromination in chloroform,provided an efficient method for preparing vanillin using methanol as solvent.The overall yield of reactions was 62 4%.
出处
《煤炭转化》
CAS
CSCD
1998年第3期85-87,共3页
Coal Conversion
关键词
香兰素
合成
对甲酚
香料
合成香料
vanillin,synthesis,p cresol,liquid phase oxidation,monobromination,methoxidation
