摘要
目的探讨深部真菌感染对于恶性肿瘤患者的影响,以及住院期间应注意的问题。方法调查分析2005年1月到2008年12月期间住院的76例恶性肿瘤患者院内深部真菌感染情况,分析患者一般状态、诊治方法的影响。结果76例患者中真菌感染的部位以呼吸道为主(70.9%),泌尿系次之(17.7%);病原学检测标本共培养出真菌79株,以白色念珠菌占第1位(60.8%),热带念珠菌占第2位(21.5%);老年(≥60岁)、一般状态评分(PS评分)>2分、晚期肿瘤差异均有显著性;多数有侵入性操作者(100%)、经过抗生素治疗者(97.4%)、经过激素治疗者(90.8%)和经过放化疗治疗者(82.9%)。结论肿瘤患者的年龄、病情分期、一般状态是本组病例发生院内深部真菌感染的基本病因,抗生素不合理使用及住院期间侵入性操作、既往放化疗及激素治疗等医疗措施是院内深部真菌感染的危险因素。
Objective To explore the impact of deep nosocomial fungal infection on tumor patients. Method Chnical data including performance status, diagnosis and treatment of 76 tumor patients with deep nosocomial fungal infection during 2005 to 2008 were investigated and analysed. Result In the 76 patients, the rate of respiratory tract infection was the highest （70.9%）, followed by urological tract infection （ 17.7% ）. Of the 79 strains of fungi detected, candida albicans was predominant （60.8%）, followed by candida tropicalis （21.5%）. There were significant differences between ages, performance status （PS） and stages, respectively. Patients who underwent invasive operation accounted for 100%, while those who were given antibiotics, hormone therapy and radio-and chemotherapy accounted for 97.4% 90. 8% and 82.9% respectively. Conclusion The results proved that the age, stage and PS were the basic factors of deep nosocomical fungal infection, while irrational use of antibiotics, frequent invasive operations as well as past treatment such as hormone-, radio-and themotherapy were the risk factors.
出处
《中国微生态学杂志》
CAS
CSCD
2009年第6期538-539,542,共3页
Chinese Journal of Microecology
