摘要
目的:探讨有氧运动对冠心病患者C-反应蛋白(CRP)及肿瘤坏死因子-α(TNF-α)的影响。方法:60例平时不运动的冠心病稳定型心绞痛患者被随机分为运动组(有氧运动+药物治疗)、药物治疗组(单纯药物治疗),另选30例正常人作为正常对照组。所有人在治疗前与治疗24周结束后,以酶联免疫吸附试验测定血清中CRP,以放射免疫法测定血清中TNF-α水平;并测定实验前后的体重。结果:治疗前药物对照组及运动组血清CRP、TNF-α水平明显高于正常对照组(P<0.05～<0.01)。治疗24周后运动组血清中CRP、TNF-α水平明显下降,且低于药物治疗组(P<0.05),但仍明显高于正常对照组(P<0.05);运动组病人体重明显低于药物治疗组(P<0.05)。结论:有氧运动可以减轻冠心病患者的炎症反应,且伴有体重的减轻。
To explore the effects of aerobic exercise on C--reactive protein （CRP） and Tumor necrosis factor （TNF）--α in coronary heart disease patients （CHD）. Methods： Sixty stable CHD patients were randomly divided into two groups： aerobic exercise group （exercise group, participated in a 12--week aerobic exercise training and with drug treatment） ; drug treatment group （drug control group, only treated with drag）. Another thirty health adults composed normal control group. Fasting blood samples were collected before treated and on 6 months after treated. CRP levels were measured by enzyme linked immunosorbent assay; TNF-α levels were measured by radio-immunity. Results.. Before treatment, the CRP and TNF--α level were more than those of normal control group （P〈0. 05 -0.01） ; After 24 weeks treatment, the body weight, CRP and TNF--α levels in exercise group considerably reduced and less than those of drag control group （P〈0.05 all）. Conclusion： Aerobic exercise training significantly decrease weight and exerts anti-inflammatory effects in patients with coronary heart disease.
出处
《心血管康复医学杂志》
CAS
2009年第3期216-219,共4页
Chinese Journal of Cardiovascular Rehabilitation Medicine
关键词
运动
冠状动脉疾病
C反应蛋白质
肿瘤坏死因子
Exercise
Coronary artery disease
C--reactive protein
Tumor necrosis factor-alpha
