摘要
目的探讨多肿瘤基因在乳腺癌组织中的表达情况,揭示其与乳腺癌病理生物学特性的关系,以及这些基因在乳腺癌发生发展中的相互关系。方法采用免疫组化SP染色法对120例乳腺癌组织中多肿瘤基因的表达进行检测(ER,PR,C-erbB-2,p53,nm23,Bcl-2,PCNA,MRP),分析其与乳腺癌病理生物学特性的关系。结果(1)p53、Bcl-2的表达在不同乳腺癌激素受体状态中有显著性差异,且与ER、PR的表达有显著相关性:p53在ER(-)、PR(-)的乳腺癌中呈现高表达,在ER(+)、PR(+)的乳腺癌中呈现低表达;而Bcl-2则相反。(2)Bcl-2的表达与月经状态有关,在绝经前乳腺癌组织中的表达明显高于绝经后乳腺癌。(3)PCNA的表达与肿瘤的大小有关,在直径较大的肿瘤(>3 cm)的表达显著高于直径较小的肿瘤。结论p53、Bcl-2的表达与ER、PR的状态显著相关,可作为判断乳腺癌生物学特性和预后的重要指标。
Objective To observe multioneogenes expression and investigate their relations with pathobiological characteristic in breast cancer. Methods The SP immunohistoehemical staining method were adopted to examine the expressions of multioncogenes （ER, PR, C-erbB-2, p53, nm23, Bcl-2, PCNA, MRP） in 120 samples of breast cancer tissues. Results The expressions of p53,Bcl-2 were eorrelatd with ER,PR state： the expression of p53 was significantly higher in ER,PR negative expressions than that in ER,PR positive expressions,P〈0.01; the expression of Bcl-2 was significantly lower in ER,PR negative expressions than that in ER, PR positive expressions, P〈0. 005. Moreover, the expression of Bcl-2 in premenopause was significantly higher than that in postmenopause,P〈0.01. The expression of PCNA was correlatd with tumor size： it was significantly higher in patients with tumor size 〉3 cm than that in patients with tumor size ≤3 cm. Conclusions The expressions of p53,Bcl-2 were significantly correlatd with ER, PR state and may be used as important index to estimate the biological behaviour and prognosis of breast cancer.
出处
《空军总医院学报》
2008年第4期226-228,共3页
Journal of General Hospital of Air Force,PLA
关键词
乳腺肿瘤/病理学
基因表达
肿瘤转移
预后
Breast neoplasms/pathology
Gene expression
Neoplasm metastasis
Prognosis
