摘要
目的探讨细胞骨架连接蛋白Ezrin在不同肝组织的表达情况,及其可能的临床意义。方法选择行手术或肝穿刺患者61例,其中肝癌30例,肝硬化患者23例,正常肝组织8例,免疫组织化学检测各组肝脏组织中Ezrin的表达情况。结果肝癌组织Ezrin的阳性表达率明显高于癌旁组织、肝硬化组织、正常肝组织,差异有统计学意义(P<0.01);低分化肝癌组织中Ezrin阳性表达率明显高于中、高分化的肝癌组织;肿瘤直径大于3cm的肝癌组织Ezrin的阳性表达率明显高于肿瘤直径小于3cm的肝癌组织;发生转移的肝癌组织Ezrin阳性表达率明显高于未发生转移的肝癌组织。结论Ezrin的高表达与肝癌的发生发展具有一定的关系。
Objective To explore the expression of Ezrin in hepatocellular carcinoma （HCC） tissues and its clinical significance. Methods Sixty one eases of hepatic tissues including 30 cases of HCC, 23 cases of hepatic cirrhosis, 8 cases of normal hepatic tissues were selected. The expression of Ezrin in these tissues were tested with immunohistochemistry. Results The positive rate of Ezrin expression in HCC tissues was significantly higher than tissues adjacent to hepatic cancer, hepatic cirrhosis tissues and normal hepatic tissue group （ P 〈 0. 01 ）. The positive rate of Ezrin in the low differentiation HCC tissues was significantly higher than that in high and middle differentiation HCC tissues. The positive rate of Ezrin in the HCC tissues that tumor 〉 3 cm was significantly higher than that in the HCC tissues that tumor≤3 cm. The positive rate of Ezrin in the tissues with metastasis was significantly higher than that in the tissues without metastasis. Conclusions The high ex- pression of Ezrin may have relationship with the development of hepatic carcinoma.
出处
《国际内科学杂志》
CAS
2009年第6期321-323,F0003,共4页
International Journal of Internal Medicine
基金
河北省中医药管理局科学研究计划项目课题(2007066)
关键词
EZRIN
肝癌
肝硬化
肿瘤转移
Ezrin
Hepatic carcinoma
Hepatic cirrhosis
Metastasis of tumor
