摘要
Pin1是人类肽基脯氨酰顺反异构酶,能特异性地识别结合磷酸化的丝氨酸/苏氨酸-脯氨酸(pSer/Thr-Pro)基序,改变蛋白质的构象,影响其活性和稳定性。目前已发现多种Pin1的底物,包括RNA聚合酶Ⅱ、转录因子、免疫调节物等。Pin1与底物相互作用,在细胞周期调控、神经病理及免疫调节过程中发挥重要的作用。Pin1受转录水平以及翻译后磷酸化和氧化修饰调节,其水平变化或调控紊乱会导致肿瘤、阿尔茨海默病及其他疾病的发生。
The peptidyl prolyl cis/trans isomerase Pinl specifically binds phosphorylated Ser/Thr-Pro protein motifs and catalyzes the cis/trans isomerization of the peptide bond, changes the conformation and influences the stability and activity of the substrates. To date, a subset of proteins has been identified as substrates for Pinl. Pinl interacts with its substrates and plays crucial roles in cell cycle, neural pathology and immune response. Accumulating studies have revealed that Pinl isomerase activity is regu- lated by its post-translational modifications, including phosphorylation and oxidation. Over-expression or regulative imbalance of Pinl plays an important role in the pathogenesis and therapeutics of human diseases such as cancer and AD.
出处
《医学研究生学报》
CAS
2009年第5期531-535,共5页
Journal of Medical Postgraduates
基金
国家自然科学基金资助项目(批准号:30871200)
关键词
PIN1
翻译后修饰
底物
调节机制
Pinl
Post-translational modifications
Substrates
Regulatory mechanism