摘要
目的:研究螺旋断层放疗(helical tomotherapy,HT)和常规静态调强放射治疗(IMRT)在前列腺癌治疗中的剂量学特点及危及器官保护方面所存在的差异。方法:选择10例已行螺旋断层放射治疗的早期前列腺癌患者的CT图像,统一勾画肿瘤靶体积及危及器官后,分别传输至螺旋断层放疗计划系统和常规静态调强治疗计划系统,统一给予肿瘤处方剂量76Gy/35次。结果:HT计划的剂量均匀性指数与IMRT计划相似,HT计划在直肠和膀胱的V20、V30、V40和V50均比IMRT计划小;双侧股骨头在V20、V30和V40均显著低于IMRT计划。结论:两种治疗计划的剂量学分布均能满足临床治疗所需,但HT比常规静态IMRT更陡峭的剂量梯度,并可更好地保护肿瘤周围的器官。
Objective： To study the difference in dosimetric characteristics and protection of organs at risk （OAR） between helical tomotherapy （HT） and routine intensity modulated radiation therapy （IMRT） for prostate cancer. Methods： CT images of 10 patients with local prostate cancer were delineated and transferred to HT and IMRT planning systems. Clinical target volume （CTV） was contoured on CT slices of each patient. The prescription dose of IMRT was 76Gy/35 F for the PTV. Isodose line and dose volume histograms （DVH） were used to evaluate the dose distribution in OAR. Results ： No statistically significant difference was found in homogeneity index （HI） between HT and IMRT. Compared with IMRT, HT notably reduced the volume of rectum and bladder at 20, 30, 40 and 50Gy （P 〈 0.05）. The volume of femoral head at 20, 30 and 40Gy was reduced after HT and IMRT. Conclusion： The two treatment modalities can satisfy clinical requirements. HT has a better dose distribution and protective effect for organs at risk than IMRT.
出处
《军医进修学院学报》
CAS
2009年第3期315-317,共3页
Academic Journal of Pla Postgraduate Medical School
