摘要
缺血性卒中是一个复杂性状的多基因遗传病，遗传流行病学研究结果提示遗传变异决定了其遗传易感性。近年来缺血性卒中遗传学的研究取得了长足的进展，通过连锁分析和关联分析陆续报告了一些与缺血性卒中相关的新的易感基因。5-脂氧合酶激活蛋白（5-lipoxygenase activating protein，ALOXSAP）基因是2004年鉴定出来的第一个与缺血性卒中密切相关的基因。本文就ALOXSAP基因多态性与缺血性卒中相关性的研究进展作一综述。
Ischemic stroke （IS） is a complex multifactorial disorder. The results of genetic epidemiological studies suggest that hereditary susceptibility is caused by genetic variants. In recent years much more progress in IS genetics research has been made through linkage and association analysis, and some new IS susceptible genes has been reported. 5-1ipoxygenase activating protein （ALOX5AP） gene was identified as the first susceptible gene which was closely related with IS in 2004. In this article the research progress of genetics in IS and the association of ALOX5AP polymorphisms with IS was reviewed.
出处
《中国卒中杂志》
2009年第5期429-434,共6页
Chinese Journal of Stroke
