摘要
目的为探讨遗尿症的遗传方式，我们从遗传异质性和时间进传学方面对遗尿症进行了初步研究。方法对4个遗尿症家系（132人）进行家系、心理状态和遗尿解除时间等因素调查分析。结果4个遗尿症家系中，有2个家系为从性显性遗传，2个家系为常染色体隐性遗传，遗尿症存在着遗传异质性；时间遗传学分析发现近尿症的时间子也是世代相传，并表现为主德尔式遗传；揭示在不同家系中决定遗尿症的基因虽然相同，但由于时间子的不同，从而表现出同是遗尿症却在不同的家系中，有不同的解除遗尿时间，而在同一家系中，由于三维子和时间子均相同，因而表现出相似的解除遗尿时间。结论遗尿症存在着遗传异质性，即具有不同的遗传方式；解除遗尿的时间也表现为孟德尔式遗传。
Objective To explore the inheritance mode of enuresis, four pedigrees of enuresis on heterogeneity and chronogenetics. Method Four pedigrees of enuresis was analysed by pedigree methood,psychological states and the time of relieving enuresis and so on were investigated. Results Two pedigrees of enuresis was inherited as sex-influenced dominant(only expressive in men and determined by the autosomal dominant in men and recessive in women)as first reported; 2 pedigrees was inherited as autosomal recessives; This disease have heterogeneity. The chronon of enuresis was inherited as Mendelian inheritance by chronogenetics method, this disease have different time of relieving enuresis among different family because they have different chronon though they have same gene of enuresis, it have same time of relieving enuresis in same family because they have same chronon and gene of enuresis. Conclusion Enuresis have heterogeneity,the time of relieving
出处
《实用儿科临床杂志》
CAS
CSCD
1998年第2期68-70,共3页
Journal of Applied Clinical Pediatrics
关键词
遗尿症
遗传异质性
时间遗传学
enuresis
sex-influenced dominance
chronogenetics
heterogeneity
