摘要
以川芎嗪为对照，研究其代谢产物２－羟甲基－３，５，６－三甲基吡嗪（１）对心血管系统的药理作用。结果表明，１能明显延长小鼠心电消失时间和血液凝固时间，能明显降低大鼠主动脉血压，但对大鼠心率无明显影响，提示１有改善心肌耐缺氧能力。
The cardiovascular effects of 2hydroxymethyl3,5,6trimethyl pyrazine (1[STBZ〗), one of the major metabolites of tetramethylprazine, were studied. 1 significantly prolonged cardiac potential lasting time and blood coagulating time in mice. It also significantly deduced the arterial blood pressure but had no effect on heart rates in rats. It was demonstrated that 1 improved the anoxemiaresistant ability and had the effects of antihypertention and anticoagulation.
出处
《中国医药工业杂志》
CAS
CSCD
北大核心
1998年第6期258-260,共3页
Chinese Journal of Pharmaceuticals
关键词
川芎嗪
三甲基吡嗪
心血管系统
药理作用
tetramethylpyrazine, metabolite, 2hydroxymethyl3,5,6trimethylpyrazine, cardiovascular system, pharmacological action
