摘要
采用几种化学及生物学模型考察了染料木素乙酰阿魏酸酯的清除自由基能力、螯合金属离子能力及保护DNA免受自由基损伤能力。研究结果表明,染料木素酯化修饰物比染料木素具有更强的清除DPPH·、·OH自由基的能力,且保护DNA免受羟基自由基损伤的能力与染料木素相当,但染料木素酯化修饰物比染料木素螯合金属Fe2+离子的能力有一定程度的减弱。此外,本文还探讨了酯化产物与其抗氧化及清除自由基活性之间的构效关系,为寻求与自由基相关疾病新药的发现、食用功能因子的开发等奠定实验基础。
The abilities of free radical scavenging and ferrous iron chelating and inhibition of hydroxyl radicalsmediated DNA degradation of genistein acetyfferulic acid esters were evaluated by using various chemical and biological assays.The results showed that the abilities of two genistein acetylferulic acid esters in scavenging free radical of DPPH · and · OH were stronger than genistein.Two esters exhibited almost the same good protecting effect on DNA damage caused by hydroxyl radicals as genistein.Ferrous ion chelating activities of two esters appeared to have abated somewhat than genistein.We studied their structure-effective relationship in this article for the sake of establishing experiment foundation of finding new drugs about diseases induced by free radical and developing dietary function factor.
出处
《食品工业科技》
CAS
CSCD
北大核心
2009年第5期65-67,71,共4页
Science and Technology of Food Industry
基金
国家自然科学基金项目(20562008)
长江学者和创新团队发展计划(IRT0540)资助项目
关键词
染料木素
阿魏酸
酯化修饰物
抗氧化
清除自由基
genistein
ferulic acid
genistein acetylferulic acid esters
antioxidant
free radical scavenging
