摘要
目的:建立过度训练大鼠模型,探讨大豆多肽对过度训练大鼠肠道免疫功能的干预作用。方法:将大鼠随机分为对照组(C)、过度训练组(OT)和大豆多肽干预组(OS)。检测各组大鼠小肠组织SIgA、Gln的含量以及小肠CD4+、CD8+T细胞数量。结果:与对照组比较,过度训练组大鼠小肠组织中SIgA和Gln含量显著下降,CD4+T细胞数量、CD4+/CD8+比值显著下降,小肠CD8+T细胞数量显著升高;与OT组相比,CD4+T细胞数量、CD4+/CD8+的比值显著升高,CD8+T细胞的数量显著降低。结论:过度训练导致大鼠肠道免疫功能显著下降,过度训练时大鼠小肠Gln水平下降,可能是过度训练引起肠道免疫功能降低的主要机制。补充大豆多肽可显著改善长期大负荷运动训练大鼠肠道免疫功能,其确切机制还有待进一步深入研究。
Objective： To establish rat model for overtraining and explore the intervention effect of soybean peptide supplementation on the intestinal immune function of overtraining rats and its mechanism. Method： Experimental rats were randomly divided into control group, overtraining group, and soybean peptide intervention group. The content of Gln, sIgA and CD4＋, CD8＋ quantity in small intestine were examined. Results： Compared with the control group, in the small intestine tissue of overtraining group, slgA, Gin content, CD4＋ quantity and the CD4＋/CD8＋ ratio obviously decreased, CD8＋ quantity obviously increased. Compared with the overtraining group, in the small intestine of OS group, sIgA and Gln had a trend of increasing, but had no significant difference, but CD4＋ quantity, CD4＋/CD8＋ ratio increased significantly, CD8＋ quantity obviously reduced. Conclusion： Overtraining might cause immunologic function in small intestinal tract of rats to reduce obviously. In the small intestinal tissue of rats with overtraining, the significant decrease of Gin concentration might be main mechanism that overtraining causes immunologic function in the intestinal tract to reduce. Supplement of SPI could improve immunologic function in small intestinal tract of rats with long-term overtraining. The exactly intervention mechanism which SPI supplement prevented the decrease of immunologic function in the intestinal tract need further research.
出处
《天津体育学院学报》
CAS
CSSCI
北大核心
2009年第3期209-211,共3页
Journal of Tianjin University of Sport
基金
国家科技部攻关课题(项目编号:2001BA904b17)
江苏省教育厅自然科学基金项目(项目编号:E0109188)
关键词
过度训练
大豆多肽
肠道免疫功能
overtraining
soybean peptide
intestinal immunity iunction
