摘要
目的:探讨沙美特罗替卡松粉吸入剂对初入高海拔地区青年肺功能的影响。方法:将34名受试者随机分为沙美特罗组(n=18)和对照组(n=16),自海拔1 400m历时5天进入5 200m,从进入海拔5 200m当天开始,沙美特罗组每天早晚各1次吸入沙美特罗替卡松粉1个剂量(沙美特罗100μg,丙酸氟替卡松200μg),连续5天;对照组用同样的方法吸入少量生理盐水。于吸入沙美特罗替卡松粉吸入剂第5天检测两组受试者的肺功能,检测指标包括FVC、FEV1、FEV1%、MMEF、PEF和MVV。结果:沙美特罗组较对照组肺功能指标中,FVC[(3.84±0.66)L vs(3.32±0.54)L],FEV1[(3.78±0.62)Lvs(3.25±0.58)L],MMEF[(6.36±1.80)L/s vs(5.11±1.23)L/s],PEF[(8.99±2.04)L/s vs(7.54±1.88)L/s],MVV[(142.30±17.73)L vs(124.34±21.34)L]显著增高(P<0.05);FEV1%[(97.86±6.06)Lvs(95.82±7.53)L]无显著性变化(P>0.05)。结论:在高原吸入沙美特罗替卡松粉吸入剂能提高移居者的肺通气功能。
Objective. To estimate the effect of salmeterol on pulmonary function of healthy young men firstly exposed to high altitude. Methods：34 subjects, who were exposed to an altitude of 5 200m （chronometer spot） from 1 400mlasted for 5 days, were assigned to receive salmeterol aspiration （100gg salmeterol＋200μg fluticasone propionate, twice/day ） for 5 days （experiment group, n=18） and to receive 0. 9%saline aerosol （control group,n=16） that day. Pulmonary function including FVC, FEV1, FEV1%, MMEF, PEF and MVV was tested on the day 5 post--reatment, Results：As compared with control group, FVC[（3. 84±0. 66）L vs （3. 32±0. 54）L], FEV1[（3. 78±0. 62） L vs （3. 25±0. 58）L], MMEI1（6. 36±1. 80）L/s vs （5. 11±1. 23）L/s], PEF[（8. 99±2. 04）L/s vs （7. 54±1. 88）L/ s],MVV[（142. 30±17. 73） L vs （124. 34±21. 34）L]in experiment group were increased significantly （P〈0. 05）. Conclusions：Salmeterol can improve lung function of healthy adults acute exposed to high altitude.
出处
《高原医学杂志》
CAS
2009年第1期5-7,共3页
Journal of High Altitude Medicine
