摘要
采用氧化铍一次性气管内注入染毒的方法制备豚鼠铍病模型。肺组织病理观察显示，染毒早期病变为呼吸系统化学性炎症，表现为支气管炎、肺炎及肺水肿。后期以淋巴细胞、上皮样细胞和多核巨细胞肉芽肿病变明显。电镜观察见铍病豚鼠肺泡间隔增宽，偶见胶原增生，肺泡Ⅱ型细胞增生，其细胞内板层体亦增多。
Suspension of BeO in sterile NS(10g/L) 1ml was injected endotracheally in guinea pigsThe pulmonary histopathological observation was taken week by weekThe light microscope showed that a chemical bronchitis and pneumonia were developed in early stage,and granulomatous disease composed by lymphocyles,epithelioid cells and multinucleated giant cells was formed in late stage after BeO endolracheal injectionThe electronic microscope showed the thickening of interalveolar septa with multiple collagens;hyperplasia of type Ⅱ cells and increase of lamella bodies were also shown
出处
《职业医学》
1998年第1期8-10,共3页
China Occupational Medicine
关键词
铍病
动物模型
病理形态学
职业病
beryllium disease,experimental model for beryllium disease,histopathological observation
